Apoptosis and apoptosis-related proteins in thyroid myopathies

Maria C. Monici, Carmelo Rodolico, Antonio Toscano, Sonia Messina, Salvatore Benvenga, Corrado Messina, Giuseppe Vita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

DNA fragmentation and apoptosis-related proteins have been investigated in thyroid cells and there is evidence that Fas-mediated apoptosis is inhibited by thyroid stimulating hormone (TSH). We investigated DNA fragmentation by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), and Bcl-2 and Fas antigen expression by immunocytochemistry in skeletal muscles from 12 patients with hypothyroid myopathy and 5 patients with hyperthyroid myopathy, The finding of very few TUNEL-positive muscle fibers in both conditions suggests that apoptosis does not play a role in the pathogenesis of thyroid myopathies. Bcl-2 expression increased significantly in hypothyroid myopathy, correlating with high serum TSH levels, and not with either triiodothyronine (T3) or thyroxine (T4) serum levels. By contrast, Fas antigen was overexpressed in hyperthyroid myopathy, correlating with low TSH levels. These findings suggest an anti-apoptotic role for TSH itself in skeletal muscle.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalMuscle and Nerve
Volume26
Issue number3
DOIs
Publication statusPublished - Sep 2002

Fingerprint

Muscular Diseases
Thyrotropin
Thyroid Gland
Apoptosis
CD95 Antigens
DNA Fragmentation
Hyperthyroidism
Proteins
Skeletal Muscle
DNA Nucleotidylexotransferase
Triiodothyronine
Transferases
Serum
Thyroxine
Immunohistochemistry
Muscles

Keywords

  • Apoptosis
  • Bcl-2
  • Fas antigen
  • Thyroid myopathy
  • Thyroid stimulating hormone

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Monici, M. C., Rodolico, C., Toscano, A., Messina, S., Benvenga, S., Messina, C., & Vita, G. (2002). Apoptosis and apoptosis-related proteins in thyroid myopathies. Muscle and Nerve, 26(3), 383-388. https://doi.org/10.1002/mus.10212

Apoptosis and apoptosis-related proteins in thyroid myopathies. / Monici, Maria C.; Rodolico, Carmelo; Toscano, Antonio; Messina, Sonia; Benvenga, Salvatore; Messina, Corrado; Vita, Giuseppe.

In: Muscle and Nerve, Vol. 26, No. 3, 09.2002, p. 383-388.

Research output: Contribution to journalArticle

Monici, MC, Rodolico, C, Toscano, A, Messina, S, Benvenga, S, Messina, C & Vita, G 2002, 'Apoptosis and apoptosis-related proteins in thyroid myopathies', Muscle and Nerve, vol. 26, no. 3, pp. 383-388. https://doi.org/10.1002/mus.10212
Monici MC, Rodolico C, Toscano A, Messina S, Benvenga S, Messina C et al. Apoptosis and apoptosis-related proteins in thyroid myopathies. Muscle and Nerve. 2002 Sep;26(3):383-388. https://doi.org/10.1002/mus.10212
Monici, Maria C. ; Rodolico, Carmelo ; Toscano, Antonio ; Messina, Sonia ; Benvenga, Salvatore ; Messina, Corrado ; Vita, Giuseppe. / Apoptosis and apoptosis-related proteins in thyroid myopathies. In: Muscle and Nerve. 2002 ; Vol. 26, No. 3. pp. 383-388.
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