Apoptosis and carcinogenesis; A perspective through transglutaminase, one of the key participants in the molecular program of apoptosis

Research output: Contribution to journalArticle

Abstract

Apoptosis for a long time has been viewed as an obscure morphologic phenomenon without specific molecular determinants. Several components of the molecular mechanism leading to apoptosis have been recently revealed; one of these is the induction and activation of the protein cross-linker tissue transglutaminase during the process. Blocking apoptosis increases the life-span of cells as well as the chance of protooncogene activation and uncontrolled tumor growth. However, the apoptotic program remains accessible in malignant cells providing a physiological way for the elimination of malignant cell populations.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalClinical Chemistry and Enzymology Communications
Volume6
Issue number1-2
Publication statusPublished - 1993

Keywords

  • Apoptosis
  • Life-span of cells
  • Malignant transformation
  • Molecular mechanism
  • Transglutaminase

ASJC Scopus subject areas

  • Clinical Biochemistry

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