Apoptosis and gastrointestinal tract

R. Ciccocioppo

Research output: Contribution to journalArticlepeer-review

Abstract

The gastrointestinal tract is characterized by a rapid proliferation of stern cells that differentiate to become terminal mature cells and ultimately die through a genetically programmed form of cell death, termed apoptosis, which is responsible for maintaining of tissue size. Apoptosis has also been shown to play an important role in the pathophysiology of several gastrointestinal diseases. The development of many infectious and immune-mediated diseases, such as gastritis, coeliac disease, inflammatory bowel diseases, may be triggered by the prevalence of pro-apoptotic signals, whereas prolonged cell survival, due to apoptosis inhibition, may give rise to neoplastic clones. Elucidation of the biochemical pathways and of specific proteins regulating apoptosis may provide a remarkable opportunity to manipulate the life and death decisions of the gastrointestinal cells and to develop new, therapeutic strategies. This review will deal with the mechanisms potentially involved in apoptosis and with the clinical relevance of this phenomenon in gastrointestinal diseases.

Original languageEnglish
Pages (from-to)162-172
Number of pages11
JournalItalian Journal of Gastroenterology and Hepatology
Volume31
Issue number2
Publication statusPublished - 1999

Keywords

  • Apoptosis
  • Enterocyte turnover
  • Gastrointestinal diseases
  • Gastrointestinal tract
  • Oncogenesis

ASJC Scopus subject areas

  • Gastroenterology

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