Apoptosis as programmed cell death (PCD): Cupio dissolvi in cell life

S. Pileri, S. Poggi, E. Sabattini, S. Santucci, G. Melilli, B. Falini, P. Tosi

Research output: Contribution to journalArticle

Abstract

Apoptosis is a distinct form of cell death in multicellular organisms, displays characteristic morphologic features, and represents the only currently recognised form of programmed cell death (PCD). It is a process that requires an actively functioning metabolism with protein synthesis, the stimulation of specific enzymatic pathways, and in most cases, gene transcription. In mammals various genes which include c-myc, bcl-2, spg-2, p53 and ras help regulate apoptosis. The activation or repression of the various genes depends on the stimulus of extracellular signals, most often captated by specific receptors. Apoptosis plays a fundamental role in normal tissue development and renewal, immune system responses, and the progression of pathological conditions such as AIDS and tumours. This article reviews the main morphologic, biochemical and genetic aspects of the phenomenon, together with its impact on the natural history and response to therapy of some diseases.

Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalCurrent Diagnostic Pathology
Volume1
Issue number1
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Apoptosis as programmed cell death (PCD): Cupio dissolvi in cell life'. Together they form a unique fingerprint.

  • Cite this

    Pileri, S., Poggi, S., Sabattini, E., Santucci, S., Melilli, G., Falini, B., & Tosi, P. (1994). Apoptosis as programmed cell death (PCD): Cupio dissolvi in cell life. Current Diagnostic Pathology, 1(1), 48-55. https://doi.org/10.1016/S0968-6053(06)80009-8