Apoptosis Biochemical events and relevance to cancer chemotherapy

Soumitra Sen, Maurizio D'Incalci

Research output: Contribution to journalArticlepeer-review


Two distinct pathways for cell death exist. Compared to necrotic death, physiological or apoptotic cell death is an active suicidal process that consists of a cascade of well-regulated synthetic events. Participation of specific genes in apoptosis, and its possible molecular regulation, are considered in order to investigate the mechanism of cell death induced by some cancer chemotherapeutic agents.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalFEBS Letters
Issue number1
Publication statusPublished - Jul 27 1992


  • Anticancer agent
  • bcl-2
  • Calcium
  • Cell cycle phase
  • p34, p53
  • Programmed cell death
  • Regulation
  • Sulphated glycoprotein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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