Apoptosis Biochemical events and relevance to cancer chemotherapy

Soumitra Sen; Maurizio D'Incalci

doi:10.1016/0014-5793(92)80914-3

Apoptosis Biochemical events and relevance to cancer chemotherapy

Soumitra Sen, Maurizio D'Incalci

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Two distinct pathways for cell death exist. Compared to necrotic death, physiological or apoptotic cell death is an active suicidal process that consists of a cascade of well-regulated synthetic events. Participation of specific genes in apoptosis, and its possible molecular regulation, are considered in order to investigate the mechanism of cell death induced by some cancer chemotherapeutic agents.

Original language	English
Pages (from-to)	122-127
Number of pages	6
Journal	FEBS Letters
Volume	307
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(92)80914-3
Publication status	Published - Jul 27 1992

Keywords

Anticancer agent
bcl-2
Calcium
Cell cycle phase
p34, p53
Programmed cell death
Regulation
Sulphated glycoprotein

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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KW - Cell cycle phase

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KW - Programmed cell death

KW - Regulation

KW - Sulphated glycoprotein

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