TY - JOUR
T1 - Apoptosis, cross-presentation, and the fate of the antigen specific immune response
AU - Bellone, M.
PY - 2000
Y1 - 2000
N2 - Induction of cell death by apoptosis, also called programmed cell death, and clearance of apoptotic bodies by scavenger cells has long thought to be an efficient means to dispose of unwanted cells without causing inflammatory responses able to mediate specific reactions. However, a number of evidences have been accumulated suggesting that apoptotic cell death is implicated in the pathogenesis of systemic and organ specific autoimmune diseases. In addition, recognition and engulfement of apoptotic cells by professional antigen presenting cells, such as dendritic cells, and their interaction with effector immune cells have been recently described to result in apoptotic cell-derived antigen specific tolerance. This review will summarise the most recent findings on the immunogenic potential of cells undergoing programmed death.
AB - Induction of cell death by apoptosis, also called programmed cell death, and clearance of apoptotic bodies by scavenger cells has long thought to be an efficient means to dispose of unwanted cells without causing inflammatory responses able to mediate specific reactions. However, a number of evidences have been accumulated suggesting that apoptotic cell death is implicated in the pathogenesis of systemic and organ specific autoimmune diseases. In addition, recognition and engulfement of apoptotic cells by professional antigen presenting cells, such as dendritic cells, and their interaction with effector immune cells have been recently described to result in apoptotic cell-derived antigen specific tolerance. This review will summarise the most recent findings on the immunogenic potential of cells undergoing programmed death.
KW - Apoptosis
KW - Cancer
KW - Cross-priming
KW - Cross-tolerance
KW - Dendritic cells
KW - T lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=0033755720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033755720&partnerID=8YFLogxK
U2 - 10.1023/A:1009671105696
DO - 10.1023/A:1009671105696
M3 - Article
C2 - 11227210
AN - SCOPUS:0033755720
VL - 5
SP - 307
EP - 314
JO - Apoptosis : an international journal on programmed cell death
JF - Apoptosis : an international journal on programmed cell death
SN - 1360-8185
IS - 4
ER -