Apoptosis in HIV infection: Protective role of IL-2

P. Cordiali Fei, M. Solmone, M. Viora, P. Vanacore, O. Pugliese, A. Giglio, F. Caprilli, F. Ameglio

Research output: Contribution to journalArticle

Abstract

Peripheral blood mononuclear cells from HIV-infected subjects have been demonstrated by different methods to die by apoptosis after short time in culture. In the present study the percentages of apoptotic cells have been measured by propidium iodide staining and flow cytometry in PBMC from healthy controls (15) and HIV-infected subjects with asymptomatic (10) or advanced (15) disease, with or without anti-viral treatment. The percentage of apoptosis significantly correlated with clinical stage (CDCII: 15.85% ± 9.17, CDCIV: 22.6% ± 5.97, P <0.001) and the CD4/CD8 CD3 cell ratio. P = -0.57, P = 0.012), while no differences were found in relation to AZT therapy. By adding IL-2 to the cultures the percentages of apoptosis of PBMC from HIV-infected patients were significantly reduced in all experiments.

Original languageEnglish
Pages (from-to)60-64
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume8
Issue number2
Publication statusPublished - 1994

Keywords

  • AIDS
  • apoptosis
  • flow cytometry
  • IL-2

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

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  • Cite this

    Cordiali Fei, P., Solmone, M., Viora, M., Vanacore, P., Pugliese, O., Giglio, A., Caprilli, F., & Ameglio, F. (1994). Apoptosis in HIV infection: Protective role of IL-2. Journal of Biological Regulators and Homeostatic Agents, 8(2), 60-64.