Apoptosis in normal and cancer stem cells

Gioacchin Iannolo, Concetta Conticello, Lorenzo Memeo, Ruggero De Maria

Research output: Contribution to journalArticle

Abstract

Cancer stem cells, previously identified in acute leukemias, have now been isolated from several human malignancies, such as breast, brain and gastrointestinal tumors. The origin of these cells is still questionable, but a growing body of evidence supports the idea that they are responsible for tumor growth and maintenance. For this reason, they have become a primary subject of investigation with a view to developing novel therapies that might lead to the eradication of neoplastic diseases. As previously demonstrated, cancer stem cells in haematological diseases have biological properties similar to those of normal adult stem cells. Therefore, better knowledge of the apoptotic machinery in stem cells might help in the development of targeted therapy for treating cancers. In this review, we discuss some concepts relating to stem cell biology, focusing on the apoptotic responses of haematopoietic and neural stem cells to conventional and novel cancer treatment strategies.

Original languageEnglish
Pages (from-to)42-51
Number of pages10
JournalCritical Reviews in Oncology/Hematology
Volume66
Issue number1
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Apoptosis
  • Cancer
  • Cancer stem cells
  • Stem cells

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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