Apoptosis induced by luteolin in breast cancer: Mechanistic and therapeutic perspectives

Salman Ahmed, Haroon Khan, Deborah Fratantonio, Muhammad Mohtasheemul Hasan, Simin Sharifi, Nazanin Fathi, Hammad Ullah, Luca Rastrelli

Research output: Contribution to journalReview article

Abstract

BACKGROUND: Breast cancer is worldwide commonly found malignancy in women and effective treatment is regarded as a huge clinical challenge even in the presence of several options. Extensive literature is available that demonstrating polyphenols, the richly introduce phytopharmaceuticals as anticancer agents. Among these polyphenols, resveratrol, silibinin, quercetin, genistein, curcumin reported to have an awesome potential against breast cancer. However, till now no comprehensive survey found about the anticarcinogenic properties of luteolin against breast cancer.

SCOPE AND APPROACH: This review targeted the available literature on luteolin in the treatment of breast cancer, effects in combination with other anticancer drugs with possible mechanisms.

KEY FINDINGS AND CONCLUSION: An outstanding therapeutic potential of luteolin in the treatment of breast cancer has been recorded not just as a chemopreventive and chemotherapeutic agent yet complemented by its synergistic effects with other anticancer therapies such as cyclophosphamide, doxorubicin, and NSAID such as celecoxib, and possible underlying mechanisms. Ideally, this review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.

Original languageEnglish
Pages (from-to)152883
JournalPhytomedicine
Volume59
DOIs
Publication statusE-pub ahead of print - Mar 10 2019

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Ahmed, S., Khan, H., Fratantonio, D., Hasan, M. M., Sharifi, S., Fathi, N., Ullah, H., & Rastrelli, L. (2019). Apoptosis induced by luteolin in breast cancer: Mechanistic and therapeutic perspectives. Phytomedicine, 59, 152883. https://doi.org/10.1016/j.phymed.2019.152883