Apoptosis of skeletal muscles during development and disease

Marco Sandri, Ugo Carraro

Research output: Contribution to journalArticle

Abstract

Cells from multicellular organisms self-destroy when no longer needed or when damaged. They do this by activating genetically controlled machineries that lead to apoptosis. Skeletal muscles in adult animals are fully differentiated syncytial cells. Apoptosis has been described in developing and, recently, in adult skeletal muscle. The cellular and molecular aspects of myoblast and myofibre apoptosis and their role in disease are analysed in this review. Alterations in the pathways that regulate myoblasts proliferation/differentiation lead to induction of apoptosis during myogenesis both in vivo and in vitro. In adult muscle myofibres apoptosis seems to start from segmental areas of myofibres often producing loss of a single myonucleus. The bcl2/bax system is active in muscle when apoptosis occurs. On the other hand conflicting results are reported on the role played by FasL/Fas system. These findings are confirmed by in vitro results on myotubes and on their susceptibility to apoptosis. Though apoptosis has been shown to occur in the skeletal muscle, the role played in diseases and the pattern followed in myogenic cells are far from being clear. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1373-1390
Number of pages18
JournalInternational Journal of Biochemistry and Cell Biology
Volume31
Issue number12
DOIs
Publication statusPublished - Dec 1999

Fingerprint

Muscle Development
Muscle
Skeletal Muscle
Apoptosis
Myoblasts
Muscles
Skeletal Muscle Fibers
Animals

Keywords

  • Apoptosis
  • Bax
  • Bcl-2
  • Caspase
  • Exercise-induced muscle damage
  • Fas
  • FasL
  • Muscular dystrophy
  • Programmed cell death
  • Skeletal muscle
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Apoptosis of skeletal muscles during development and disease. / Sandri, Marco; Carraro, Ugo.

In: International Journal of Biochemistry and Cell Biology, Vol. 31, No. 12, 12.1999, p. 1373-1390.

Research output: Contribution to journalArticle

Sandri, Marco ; Carraro, Ugo. / Apoptosis of skeletal muscles during development and disease. In: International Journal of Biochemistry and Cell Biology. 1999 ; Vol. 31, No. 12. pp. 1373-1390.
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