Apoptosis - Programmed cell death: A role in the aging process?

Daniela Monti, Leonarda Troiano, Franco Tropea, Emanuela Grassilli, Andrea Cossarizza, Daniela Barozzi, Maria Claudia Pelloni, Maria Grazia Tamassia, Giorgio Bellomo, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Cells continuously exposed to genotoxic agents, such as oxygen free radicals (OFRs), deeply involved in the aging process use a variety of cellular defense mechanisms. These defense mechanisms include DNA repair enzymes, antioxidants, poly(ADP-ribosyl)polymerase (pADPRP), and stress proteins and they constitute an integrated network. An age-related failure of the efficiency of this network can affect cell proliferation and cell death, two phenomena tightly linked and regulated. Recent data from our laboratory on the role of DNA damage and pADPRP activation and on the type of cell death induced by OFRs in human lymphocytes are reviewed. In vitro and in vivo data on possible strategies to reduce oxidative stress in lymphocytes from normal and Down syndrome subjects, by using natural compounds and trace elements, are presented. They indicate that nicotinamide and L-carnitine protect human cells from OFR-induced damage and suggest that they are possible candidates as antiaging substances.

Original languageEnglish
JournalAmerican Journal of Clinical Nutrition
Volume55
Issue numberSUPPL. 6
Publication statusPublished - Jun 1992

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Keywords

  • 3-aminobenzamide
  • Aging
  • Apoptosis
  • Carnitine
  • Cell death
  • Oxygen free radicals
  • Poly(ADP-ribosyl)polymerase
  • Zinc

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Monti, D., Troiano, L., Tropea, F., Grassilli, E., Cossarizza, A., Barozzi, D., Pelloni, M. C., Tamassia, M. G., Bellomo, G., & Franceschi, C. (1992). Apoptosis - Programmed cell death: A role in the aging process? American Journal of Clinical Nutrition, 55(SUPPL. 6).