Apoptosis-related factors (TRAIL, DR4, DR5, DcRl, DcR2, apoptotic cells) and proliferative activity in ameloblastomas

Clara Rizzardi, Pietro Leocata, Luca Ventura, Marina Zweyer, Alessandro Brollo, Manuela Schneider, Mauro Melato

Research output: Contribution to journalArticlepeer-review


Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas. Materials and Methods: The expression of TRAIL and its receptors (TRAIL-R), and the location of apoptotic cells were evaluated in 15 cases of ameloblastoma using immunohistochemistry and an in situ DNA nick-end labeling method. The proliferative activity of ameloblastomas was analyzed by determining the Ki-67 labeling index. Results: TRAIL and TRAIL-R were diffusely expressed in ameloblastomas, without clear correlation with the location of apoptotic cells. Apoptosis and proliferation were opposite in the peripheral and central components of the ameloblastomas. In some ameloblastoma variants, apoptosis and proliferation seemed to modify in the same direction. Conclusion: TRAIL and its receptors might be involved in neoplastic transformation of odontogenic epithelium and might suggest some intrinsic regulation of neoplastic cell proliferation and death in ameloblastomas, thus explaining their slow growth and inability to metastasize.

Original languageEnglish
Pages (from-to)1137-1142
Number of pages6
JournalAnticancer Research
Issue number4
Publication statusPublished - Apr 2009


  • Ameloblastoma
  • Apoptosis
  • Proliferation
  • TNF-related apoptosis-inducing ligand

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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