Abstract
Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas. Materials and Methods: The expression of TRAIL and its receptors (TRAIL-R), and the location of apoptotic cells were evaluated in 15 cases of ameloblastoma using immunohistochemistry and an in situ DNA nick-end labeling method. The proliferative activity of ameloblastomas was analyzed by determining the Ki-67 labeling index. Results: TRAIL and TRAIL-R were diffusely expressed in ameloblastomas, without clear correlation with the location of apoptotic cells. Apoptosis and proliferation were opposite in the peripheral and central components of the ameloblastomas. In some ameloblastoma variants, apoptosis and proliferation seemed to modify in the same direction. Conclusion: TRAIL and its receptors might be involved in neoplastic transformation of odontogenic epithelium and might suggest some intrinsic regulation of neoplastic cell proliferation and death in ameloblastomas, thus explaining their slow growth and inability to metastasize.
| Original language | English |
|---|---|
| Pages (from-to) | 1137-1142 |
| Number of pages | 6 |
| Journal | Anticancer Research |
| Volume | 29 |
| Issue number | 4 |
| Publication status | Published - Apr 2009 |
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Keywords
- Ameloblastoma
- Apoptosis
- Proliferation
- TNF-related apoptosis-inducing ligand
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Apoptosis-related factors (TRAIL, DR4, DR5, DcRl, DcR2, apoptotic cells) and proliferative activity in ameloblastomas. / Rizzardi, Clara; Leocata, Pietro; Ventura, Luca; Zweyer, Marina; Brollo, Alessandro; Schneider, Manuela; Melato, Mauro.
In: Anticancer Research, Vol. 29, No. 4, 04.2009, p. 1137-1142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apoptosis-related factors (TRAIL, DR4, DR5, DcRl, DcR2, apoptotic cells) and proliferative activity in ameloblastomas
AU - Rizzardi, Clara
AU - Leocata, Pietro
AU - Ventura, Luca
AU - Zweyer, Marina
AU - Brollo, Alessandro
AU - Schneider, Manuela
AU - Melato, Mauro
PY - 2009/4
Y1 - 2009/4
N2 - Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas. Materials and Methods: The expression of TRAIL and its receptors (TRAIL-R), and the location of apoptotic cells were evaluated in 15 cases of ameloblastoma using immunohistochemistry and an in situ DNA nick-end labeling method. The proliferative activity of ameloblastomas was analyzed by determining the Ki-67 labeling index. Results: TRAIL and TRAIL-R were diffusely expressed in ameloblastomas, without clear correlation with the location of apoptotic cells. Apoptosis and proliferation were opposite in the peripheral and central components of the ameloblastomas. In some ameloblastoma variants, apoptosis and proliferation seemed to modify in the same direction. Conclusion: TRAIL and its receptors might be involved in neoplastic transformation of odontogenic epithelium and might suggest some intrinsic regulation of neoplastic cell proliferation and death in ameloblastomas, thus explaining their slow growth and inability to metastasize.
AB - Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas. Materials and Methods: The expression of TRAIL and its receptors (TRAIL-R), and the location of apoptotic cells were evaluated in 15 cases of ameloblastoma using immunohistochemistry and an in situ DNA nick-end labeling method. The proliferative activity of ameloblastomas was analyzed by determining the Ki-67 labeling index. Results: TRAIL and TRAIL-R were diffusely expressed in ameloblastomas, without clear correlation with the location of apoptotic cells. Apoptosis and proliferation were opposite in the peripheral and central components of the ameloblastomas. In some ameloblastoma variants, apoptosis and proliferation seemed to modify in the same direction. Conclusion: TRAIL and its receptors might be involved in neoplastic transformation of odontogenic epithelium and might suggest some intrinsic regulation of neoplastic cell proliferation and death in ameloblastomas, thus explaining their slow growth and inability to metastasize.
KW - Ameloblastoma
KW - Apoptosis
KW - Proliferation
KW - TNF-related apoptosis-inducing ligand
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M3 - Article
C2 - 19414356
AN - SCOPUS:64949088230
VL - 29
SP - 1137
EP - 1142
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4
ER -