Apoptosome structure and regulation

Elisabetta Ferraro, Claudia Fuoco, Flavie Strappazzon, Francesco Cecconi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The apoptosome is a multimolecular complex assembled around the adaptor protein Apaf1 upon mitochondria-mediated apoptosis. The formation of the apoptosome needs the presence of ATP/dATP and cytochrome c in the cytosol and triggers the activation of caspases which - in turn - drive cell demise. Apoptosis plays a key role in the homeostasis of all multicellular organisms and, indeed, with regard to its essential components the apoptosome is evolutionary conserved. However, higher eukaryotes, according to their complexity, have evolved more complicated and finely tuned mechanisms for controlling apoptosome activity. Since apoptosome dysfunctions can cause many human diseases, this complex is also a relevant molecular target in biomedicine and the understanding of its structure and its regulation is matter of great interest for scientists.

Original languageEnglish
Title of host publicationApoptosome: An Up-and-coming Therapeutical Tool
PublisherSpringer Netherlands
Pages27-39
Number of pages13
ISBN (Print)9789048134151, 9789048134144
DOIs
Publication statusPublished - 2010

Fingerprint

Apoptosomes
Apoptosis
Caspases
Cytochromes c
Eukaryota
Cytosol
Mitochondria
Homeostasis
Adenosine Triphosphate
Proteins

Keywords

  • Apaf1
  • Ced-4
  • Cytochrome c
  • Dark
  • Mitochondria

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ferraro, E., Fuoco, C., Strappazzon, F., & Cecconi, F. (2010). Apoptosome structure and regulation. In Apoptosome: An Up-and-coming Therapeutical Tool (pp. 27-39). Springer Netherlands. https://doi.org/10.1007/978-90-481-3415-1-2

Apoptosome structure and regulation. / Ferraro, Elisabetta; Fuoco, Claudia; Strappazzon, Flavie; Cecconi, Francesco.

Apoptosome: An Up-and-coming Therapeutical Tool. Springer Netherlands, 2010. p. 27-39.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ferraro, E, Fuoco, C, Strappazzon, F & Cecconi, F 2010, Apoptosome structure and regulation. in Apoptosome: An Up-and-coming Therapeutical Tool. Springer Netherlands, pp. 27-39. https://doi.org/10.1007/978-90-481-3415-1-2
Ferraro E, Fuoco C, Strappazzon F, Cecconi F. Apoptosome structure and regulation. In Apoptosome: An Up-and-coming Therapeutical Tool. Springer Netherlands. 2010. p. 27-39 https://doi.org/10.1007/978-90-481-3415-1-2
Ferraro, Elisabetta ; Fuoco, Claudia ; Strappazzon, Flavie ; Cecconi, Francesco. / Apoptosome structure and regulation. Apoptosome: An Up-and-coming Therapeutical Tool. Springer Netherlands, 2010. pp. 27-39
@inbook{da7d555a2a67460ebca03a8ca515250e,
title = "Apoptosome structure and regulation",
abstract = "The apoptosome is a multimolecular complex assembled around the adaptor protein Apaf1 upon mitochondria-mediated apoptosis. The formation of the apoptosome needs the presence of ATP/dATP and cytochrome c in the cytosol and triggers the activation of caspases which - in turn - drive cell demise. Apoptosis plays a key role in the homeostasis of all multicellular organisms and, indeed, with regard to its essential components the apoptosome is evolutionary conserved. However, higher eukaryotes, according to their complexity, have evolved more complicated and finely tuned mechanisms for controlling apoptosome activity. Since apoptosome dysfunctions can cause many human diseases, this complex is also a relevant molecular target in biomedicine and the understanding of its structure and its regulation is matter of great interest for scientists.",
keywords = "Apaf1, Ced-4, Cytochrome c, Dark, Mitochondria",
author = "Elisabetta Ferraro and Claudia Fuoco and Flavie Strappazzon and Francesco Cecconi",
year = "2010",
doi = "10.1007/978-90-481-3415-1-2",
language = "English",
isbn = "9789048134151",
pages = "27--39",
booktitle = "Apoptosome: An Up-and-coming Therapeutical Tool",
publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Apoptosome structure and regulation

AU - Ferraro, Elisabetta

AU - Fuoco, Claudia

AU - Strappazzon, Flavie

AU - Cecconi, Francesco

PY - 2010

Y1 - 2010

N2 - The apoptosome is a multimolecular complex assembled around the adaptor protein Apaf1 upon mitochondria-mediated apoptosis. The formation of the apoptosome needs the presence of ATP/dATP and cytochrome c in the cytosol and triggers the activation of caspases which - in turn - drive cell demise. Apoptosis plays a key role in the homeostasis of all multicellular organisms and, indeed, with regard to its essential components the apoptosome is evolutionary conserved. However, higher eukaryotes, according to their complexity, have evolved more complicated and finely tuned mechanisms for controlling apoptosome activity. Since apoptosome dysfunctions can cause many human diseases, this complex is also a relevant molecular target in biomedicine and the understanding of its structure and its regulation is matter of great interest for scientists.

AB - The apoptosome is a multimolecular complex assembled around the adaptor protein Apaf1 upon mitochondria-mediated apoptosis. The formation of the apoptosome needs the presence of ATP/dATP and cytochrome c in the cytosol and triggers the activation of caspases which - in turn - drive cell demise. Apoptosis plays a key role in the homeostasis of all multicellular organisms and, indeed, with regard to its essential components the apoptosome is evolutionary conserved. However, higher eukaryotes, according to their complexity, have evolved more complicated and finely tuned mechanisms for controlling apoptosome activity. Since apoptosome dysfunctions can cause many human diseases, this complex is also a relevant molecular target in biomedicine and the understanding of its structure and its regulation is matter of great interest for scientists.

KW - Apaf1

KW - Ced-4

KW - Cytochrome c

KW - Dark

KW - Mitochondria

UR - http://www.scopus.com/inward/record.url?scp=84919690969&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919690969&partnerID=8YFLogxK

U2 - 10.1007/978-90-481-3415-1-2

DO - 10.1007/978-90-481-3415-1-2

M3 - Chapter

AN - SCOPUS:84919690969

SN - 9789048134151

SN - 9789048134144

SP - 27

EP - 39

BT - Apoptosome: An Up-and-coming Therapeutical Tool

PB - Springer Netherlands

ER -