Abstract
The progressive loss of CD4 T lymphocyte is patognomonic of Human Immunodeficiency Virus (HIV) infection and results in immunodeficiency and the appearance of acquired immunodeficiency syndrome (AIDS)-defining pathologies. Although a percentage of CD4 T lymphocytes is destroyed directly by HIV infection, a much higher proportion of lymphocytes remains uninfected and therefore must be destroyed by mechanisms not directly involving viral infection. One such mechanism is apoptotic T cell death (ATCD). ATCD in HIV infection has been shown to be: 1) secondary to cross-linking of CD4 by viral proteins; 2) mediated by both APO-1/Fas and lymphotoxin (LT); and 3) differentially modulated by type 1 and type 2 cytokines. We will briefly analyze the experimental evidences suggesting that ATCD contributes significantly to the immunopathogenesis of HIV/AIDS via depletion of CD4+ T cells. apoptosis; programmed cell death; HIV; AIDS; immunology; cytokines; T lymphocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 699-706 |
| Number of pages | 8 |
| Journal | Cell Death and Differentiation |
| Volume | 4 |
| Issue number | 8 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Cell Biology
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Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection : Pivotal factors in disease progression. / Clerici, Mario; Sarin, Apurva; Henkart, Pierre A.; Shearer, Gene M.
In: Cell Death and Differentiation, Vol. 4, No. 8, 1997, p. 699-706.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection
T2 - Pivotal factors in disease progression
AU - Clerici, Mario
AU - Sarin, Apurva
AU - Henkart, Pierre A.
AU - Shearer, Gene M.
PY - 1997
Y1 - 1997
N2 - The progressive loss of CD4 T lymphocyte is patognomonic of Human Immunodeficiency Virus (HIV) infection and results in immunodeficiency and the appearance of acquired immunodeficiency syndrome (AIDS)-defining pathologies. Although a percentage of CD4 T lymphocytes is destroyed directly by HIV infection, a much higher proportion of lymphocytes remains uninfected and therefore must be destroyed by mechanisms not directly involving viral infection. One such mechanism is apoptotic T cell death (ATCD). ATCD in HIV infection has been shown to be: 1) secondary to cross-linking of CD4 by viral proteins; 2) mediated by both APO-1/Fas and lymphotoxin (LT); and 3) differentially modulated by type 1 and type 2 cytokines. We will briefly analyze the experimental evidences suggesting that ATCD contributes significantly to the immunopathogenesis of HIV/AIDS via depletion of CD4+ T cells. apoptosis; programmed cell death; HIV; AIDS; immunology; cytokines; T lymphocytes.
AB - The progressive loss of CD4 T lymphocyte is patognomonic of Human Immunodeficiency Virus (HIV) infection and results in immunodeficiency and the appearance of acquired immunodeficiency syndrome (AIDS)-defining pathologies. Although a percentage of CD4 T lymphocytes is destroyed directly by HIV infection, a much higher proportion of lymphocytes remains uninfected and therefore must be destroyed by mechanisms not directly involving viral infection. One such mechanism is apoptotic T cell death (ATCD). ATCD in HIV infection has been shown to be: 1) secondary to cross-linking of CD4 by viral proteins; 2) mediated by both APO-1/Fas and lymphotoxin (LT); and 3) differentially modulated by type 1 and type 2 cytokines. We will briefly analyze the experimental evidences suggesting that ATCD contributes significantly to the immunopathogenesis of HIV/AIDS via depletion of CD4+ T cells. apoptosis; programmed cell death; HIV; AIDS; immunology; cytokines; T lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=0000454244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0000454244&partnerID=8YFLogxK
M3 - Article
C2 - 16465282
AN - SCOPUS:0000454244
VL - 4
SP - 699
EP - 706
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
SN - 1350-9047
IS - 8
ER -