Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: Pivotal factors in disease progression

Mario Clerici, Apurva Sarin, Pierre A. Henkart, Gene M. Shearer

Research output: Contribution to journalArticle

Abstract

The progressive loss of CD4 T lymphocyte is patognomonic of Human Immunodeficiency Virus (HIV) infection and results in immunodeficiency and the appearance of acquired immunodeficiency syndrome (AIDS)-defining pathologies. Although a percentage of CD4 T lymphocytes is destroyed directly by HIV infection, a much higher proportion of lymphocytes remains uninfected and therefore must be destroyed by mechanisms not directly involving viral infection. One such mechanism is apoptotic T cell death (ATCD). ATCD in HIV infection has been shown to be: 1) secondary to cross-linking of CD4 by viral proteins; 2) mediated by both APO-1/Fas and lymphotoxin (LT); and 3) differentially modulated by type 1 and type 2 cytokines. We will briefly analyze the experimental evidences suggesting that ATCD contributes significantly to the immunopathogenesis of HIV/AIDS via depletion of CD4+ T cells. apoptosis; programmed cell death; HIV; AIDS; immunology; cytokines; T lymphocytes.

Original languageEnglish
Pages (from-to)699-706
Number of pages8
JournalCell Death and Differentiation
Volume4
Issue number8
Publication statusPublished - 1997

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Virus Diseases
Disease Progression
Cell Death
HIV
Cytokines
T-Lymphocytes
Acquired Immunodeficiency Syndrome
Lymphotoxin-alpha
Viral Proteins
Allergy and Immunology
Lymphocytes
Apoptosis
Pathology

ASJC Scopus subject areas

  • Cell Biology

Cite this

Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection : Pivotal factors in disease progression. / Clerici, Mario; Sarin, Apurva; Henkart, Pierre A.; Shearer, Gene M.

In: Cell Death and Differentiation, Vol. 4, No. 8, 1997, p. 699-706.

Research output: Contribution to journalArticle

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