Apoptotic cells overexpress vinculin and induce vinculin-specific specific cytotoxic T-cell cross-priming

Antonella Propato, Giovanna Cutrona, Vittorio Francavilla, Massimo Ulivi, Enrico Schiaffella, Olfert Landt, Rod Dunbar, Vincenzo Cerundolo, Manlio Ferrarini, Vincenzo Barnaba

Research output: Contribution to journalArticlepeer-review

Abstract

Here we show that apoptotic cells overexpress vinculin and are ingested by dendritic cells, which subsequently cross-prime vinculin-specific cytotoxic T lymphocytes (CTLs). Successful cross-priming requires that the apoptotic cells provide maturation signals to dendritic cells through CD40-CD40 ligand (CD40L) interactions. If apoptotic cells are CD40L-, the help of a third T cell is needed for priming, indicating a regulatory role for apoptotic cells in determining priming or tolerance. Vinculin-specific CTL priming is also related to apoptosis in vivo, given that in HIV-seropositive individuals, the frequency of specific CTLs depends on the proportion of peripheral CD40L+ apoptotic cells.

Original languageEnglish
Pages (from-to)807-813
Number of pages7
JournalNature Medicine
Volume7
Issue number7
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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