Apparent diffusion coefficient value and ratio as noninvasive potential biomarkers to predict prostate cancer grading: Comparison with prostate biopsy and radical prostatectomy specimen

Francesco De Cobelli, Silvia Ravelli, Antonio Esposito, Francesco Giganti, Andrea Gallina, Francesco Montorsi, Alessandro Del Maschio

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Abstract

OBJECTIVE. The purpose of this study is to test the association between diffusionweighted MRI and prostate cancer Gleason score at both biopsy and final pathologic analysis after radical prostatectomy. SUBJECTS AND METHODS. Patients with prostate cancer (n = 72) underwent diffusion-weighted MRI (b values, 0, 800, and 1600 s/mm2) with an endorectal coil. Apparent diffusion coefficient (ADC) and ADC ratio were obtained in normal and pathologic tissue and were correlated with transrectal ultrasound-guided biopsy (n = 72) and histopathologic (n = 39) Gleason scores using the ANOVA test. ADC accuracy was estimated using ROC curves. RESULTS. Lesions suspicious for prostate cancer were detected in 65 patients. The mean ADC was 1.47 and 0.87 × 10-3 mm2/s for normal and pathologic tissue, respectively (p <0.001). When we divided the population into four groups (normal tissue and biopsy Gleason scores of 6, 7, and 8-10), then the mean ADC value was 1.47, 0.96, 0.80, and 0.78 × 10-3 mm2/s, respectively (p <0.001). The ADC ratio decreased along with an increase in biopsy Gleason score (66.9%, 56.7%, and 51.5% for Gleason scores of 6, 7 and 8-10, respectively) (ANOVA, p = 0.003) and pathologic Gleason score (ANOVA, p <0.001). ROC curves had an AUC of 0.94 and 0.86 for ADC and ADC ratio, respectively (p = 0.012 and 0.042, respectively). CONCLUSION. Decreasing ADC values may represent a strong risk factor of harboring a poorly differentiated prostate cancer, independently of biopsy characteristics.

Original languageEnglish
Pages (from-to)550-557
Number of pages8
JournalAmerican Journal of Roentgenology
Volume204
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Prostatectomy
Prostate
Prostatic Neoplasms
Neoplasm Grading
Biomarkers
Biopsy
Analysis of Variance
ROC Curve
Diffusion Magnetic Resonance Imaging
Area Under Curve

Keywords

  • Apparent diffusion coefficient
  • Apparent diffusion coefficient ratio
  • Diffusion-weighted imaging
  • Gleason score
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

@article{b1a5f7e67c8048459348e0bd0480f112,
title = "Apparent diffusion coefficient value and ratio as noninvasive potential biomarkers to predict prostate cancer grading: Comparison with prostate biopsy and radical prostatectomy specimen",
abstract = "OBJECTIVE. The purpose of this study is to test the association between diffusionweighted MRI and prostate cancer Gleason score at both biopsy and final pathologic analysis after radical prostatectomy. SUBJECTS AND METHODS. Patients with prostate cancer (n = 72) underwent diffusion-weighted MRI (b values, 0, 800, and 1600 s/mm2) with an endorectal coil. Apparent diffusion coefficient (ADC) and ADC ratio were obtained in normal and pathologic tissue and were correlated with transrectal ultrasound-guided biopsy (n = 72) and histopathologic (n = 39) Gleason scores using the ANOVA test. ADC accuracy was estimated using ROC curves. RESULTS. Lesions suspicious for prostate cancer were detected in 65 patients. The mean ADC was 1.47 and 0.87 × 10-3 mm2/s for normal and pathologic tissue, respectively (p <0.001). When we divided the population into four groups (normal tissue and biopsy Gleason scores of 6, 7, and 8-10), then the mean ADC value was 1.47, 0.96, 0.80, and 0.78 × 10-3 mm2/s, respectively (p <0.001). The ADC ratio decreased along with an increase in biopsy Gleason score (66.9{\%}, 56.7{\%}, and 51.5{\%} for Gleason scores of 6, 7 and 8-10, respectively) (ANOVA, p = 0.003) and pathologic Gleason score (ANOVA, p <0.001). ROC curves had an AUC of 0.94 and 0.86 for ADC and ADC ratio, respectively (p = 0.012 and 0.042, respectively). CONCLUSION. Decreasing ADC values may represent a strong risk factor of harboring a poorly differentiated prostate cancer, independently of biopsy characteristics.",
keywords = "Apparent diffusion coefficient, Apparent diffusion coefficient ratio, Diffusion-weighted imaging, Gleason score, Prostate cancer",
author = "{De Cobelli}, Francesco and Silvia Ravelli and Antonio Esposito and Francesco Giganti and Andrea Gallina and Francesco Montorsi and {Del Maschio}, Alessandro",
year = "2015",
month = "3",
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doi = "10.2214/AJR.14.13146",
language = "English",
volume = "204",
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TY - JOUR

T1 - Apparent diffusion coefficient value and ratio as noninvasive potential biomarkers to predict prostate cancer grading

T2 - Comparison with prostate biopsy and radical prostatectomy specimen

AU - De Cobelli, Francesco

AU - Ravelli, Silvia

AU - Esposito, Antonio

AU - Giganti, Francesco

AU - Gallina, Andrea

AU - Montorsi, Francesco

AU - Del Maschio, Alessandro

PY - 2015/3/1

Y1 - 2015/3/1

N2 - OBJECTIVE. The purpose of this study is to test the association between diffusionweighted MRI and prostate cancer Gleason score at both biopsy and final pathologic analysis after radical prostatectomy. SUBJECTS AND METHODS. Patients with prostate cancer (n = 72) underwent diffusion-weighted MRI (b values, 0, 800, and 1600 s/mm2) with an endorectal coil. Apparent diffusion coefficient (ADC) and ADC ratio were obtained in normal and pathologic tissue and were correlated with transrectal ultrasound-guided biopsy (n = 72) and histopathologic (n = 39) Gleason scores using the ANOVA test. ADC accuracy was estimated using ROC curves. RESULTS. Lesions suspicious for prostate cancer were detected in 65 patients. The mean ADC was 1.47 and 0.87 × 10-3 mm2/s for normal and pathologic tissue, respectively (p <0.001). When we divided the population into four groups (normal tissue and biopsy Gleason scores of 6, 7, and 8-10), then the mean ADC value was 1.47, 0.96, 0.80, and 0.78 × 10-3 mm2/s, respectively (p <0.001). The ADC ratio decreased along with an increase in biopsy Gleason score (66.9%, 56.7%, and 51.5% for Gleason scores of 6, 7 and 8-10, respectively) (ANOVA, p = 0.003) and pathologic Gleason score (ANOVA, p <0.001). ROC curves had an AUC of 0.94 and 0.86 for ADC and ADC ratio, respectively (p = 0.012 and 0.042, respectively). CONCLUSION. Decreasing ADC values may represent a strong risk factor of harboring a poorly differentiated prostate cancer, independently of biopsy characteristics.

AB - OBJECTIVE. The purpose of this study is to test the association between diffusionweighted MRI and prostate cancer Gleason score at both biopsy and final pathologic analysis after radical prostatectomy. SUBJECTS AND METHODS. Patients with prostate cancer (n = 72) underwent diffusion-weighted MRI (b values, 0, 800, and 1600 s/mm2) with an endorectal coil. Apparent diffusion coefficient (ADC) and ADC ratio were obtained in normal and pathologic tissue and were correlated with transrectal ultrasound-guided biopsy (n = 72) and histopathologic (n = 39) Gleason scores using the ANOVA test. ADC accuracy was estimated using ROC curves. RESULTS. Lesions suspicious for prostate cancer were detected in 65 patients. The mean ADC was 1.47 and 0.87 × 10-3 mm2/s for normal and pathologic tissue, respectively (p <0.001). When we divided the population into four groups (normal tissue and biopsy Gleason scores of 6, 7, and 8-10), then the mean ADC value was 1.47, 0.96, 0.80, and 0.78 × 10-3 mm2/s, respectively (p <0.001). The ADC ratio decreased along with an increase in biopsy Gleason score (66.9%, 56.7%, and 51.5% for Gleason scores of 6, 7 and 8-10, respectively) (ANOVA, p = 0.003) and pathologic Gleason score (ANOVA, p <0.001). ROC curves had an AUC of 0.94 and 0.86 for ADC and ADC ratio, respectively (p = 0.012 and 0.042, respectively). CONCLUSION. Decreasing ADC values may represent a strong risk factor of harboring a poorly differentiated prostate cancer, independently of biopsy characteristics.

KW - Apparent diffusion coefficient

KW - Apparent diffusion coefficient ratio

KW - Diffusion-weighted imaging

KW - Gleason score

KW - Prostate cancer

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