Appearance of malignant melanoma after a non-cutaneous cancer diagnosis

Ugo Bottoni, Rita Clerico, Giovanni Paolino, Marina Ambrifi, Cecilia Luci, Paola Corsetti, Stefano Calvieri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study is to find the associations between malignant melanoma (MM) and other non-cutaneous malignancies and to see whether there are possible correlations between them. Methods: We analysed a sample of 1720 patients collected by our melanoma database, to identify patients with both MM and non-cutaneous primary cancer (NCC). The incidence rate (IR) included in our database was calculated as the ratio between the observed patients with NCC and those with MM. Results: A total of 74 patients, with both NCC and MM, were included in our analysis, corresponding to 4.30% of patients with MM present in our melanoma database. After breast cancer (24.3%; IR = 1:4), the most common malignancies were lymphomas (14.8%; IR = 1:4), renal cell carcinoma (13.5%; IR = 1:7), thyroid cancer (9.4%; IR = 1:11), and prostatic carcinoma (8.1%; IR = 1:12), followed by other cancers. Among patients with lymphomas, most patients (72.7%) had a non-Hodgkin lymphoma. Our study shows a high coexistence of multiple malignancies in patients with MM. Conclusion: Although we cannot definitively confirm a true association between non-skin cancers and MM, we believe that there are sufficient links for further investigation in order to identify new aetiological factors and therapeutic targets for these cancers.

Original languageEnglish
Article number315
Journalecancermedicalscience
Volume7
Issue number1
DOIs
Publication statusPublished - May 7 2013

Keywords

  • Melanoma
  • Multiple Primary Malignancies
  • Non-Cutaneous Malignancies
  • Renal Cell Carcinoma
  • Thyroid Cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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