TY - JOUR
T1 - Appetite course over time and the risk of death in patients on chronic hemodialysis
AU - Bossola, Maurizio
AU - Di Stasio, Enrico
AU - Rosa, Fausto
AU - Dominici, Loredana
AU - Antocicco, Manuela
AU - Pazzaglia, Costanza
AU - Aprile, Irene
AU - Tazza, Luigi
PY - 2013/8
Y1 - 2013/8
N2 - Purpose: Appetite in patients on chronic hemodialysis (HD) may be constantly very good/good or fair/poor or may fluctuate up and down over time. When constantly fair/poor, appetite has been shown to be associated with older age, more comorbidities, and more hospitalizations; however, it is unknown if it predicts survival. The aim of the present study was to assess appetite monthly for 6 months in patients on chronic HD and to determine if the course of appetite over time predicts mortality. Methods: Ninety-two HD patients were evaluated at baseline for appetite, nutritional and inflammatory markers, comorbid conditions, and Charlson's comorbidity index. Appetite assessment was repeated monthly for 6 consecutive months. Survival in relation with the course of appetite over time was determined. Results: Appetite was constantly very good/good in 45 patients (Group 1), fair/poor/very poor in 30 (Group 2), and fluctuated in 17 (Group 3). Twenty-seven (29.3 %) patients died after a mean period of 28 ± 13 months. Overall, the mean survival time was 42.1 ± 1.2 months. For Groups 1, 2, and 3, the mean survival time was 46.1 ± 0.92, 37.9 ± 2.5, and 39.1 ± 3.7 months, respectively (p <0.0001). After multivariate logistic regression analysis, the course of appetite over time was not found to be an independent risk factor for mortality. Conclusions: The course of appetite over time does not seem to predict mortality in patients on chronic hemodialysis. Considering that the study included a relatively small number of patients, larger similar studies are desirable.
AB - Purpose: Appetite in patients on chronic hemodialysis (HD) may be constantly very good/good or fair/poor or may fluctuate up and down over time. When constantly fair/poor, appetite has been shown to be associated with older age, more comorbidities, and more hospitalizations; however, it is unknown if it predicts survival. The aim of the present study was to assess appetite monthly for 6 months in patients on chronic HD and to determine if the course of appetite over time predicts mortality. Methods: Ninety-two HD patients were evaluated at baseline for appetite, nutritional and inflammatory markers, comorbid conditions, and Charlson's comorbidity index. Appetite assessment was repeated monthly for 6 consecutive months. Survival in relation with the course of appetite over time was determined. Results: Appetite was constantly very good/good in 45 patients (Group 1), fair/poor/very poor in 30 (Group 2), and fluctuated in 17 (Group 3). Twenty-seven (29.3 %) patients died after a mean period of 28 ± 13 months. Overall, the mean survival time was 42.1 ± 1.2 months. For Groups 1, 2, and 3, the mean survival time was 46.1 ± 0.92, 37.9 ± 2.5, and 39.1 ± 3.7 months, respectively (p <0.0001). After multivariate logistic regression analysis, the course of appetite over time was not found to be an independent risk factor for mortality. Conclusions: The course of appetite over time does not seem to predict mortality in patients on chronic hemodialysis. Considering that the study included a relatively small number of patients, larger similar studies are desirable.
KW - Appetite
KW - Hemodialysis
KW - Longitudinal
KW - Risk of death
UR - http://www.scopus.com/inward/record.url?scp=84881476992&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881476992&partnerID=8YFLogxK
U2 - 10.1007/s11255-012-0212-2
DO - 10.1007/s11255-012-0212-2
M3 - Article
C2 - 22684764
AN - SCOPUS:84881476992
VL - 45
SP - 1091
EP - 1096
JO - International Urology and Nephrology
JF - International Urology and Nephrology
SN - 0301-1623
IS - 4
ER -