Appetite course over time and the risk of death in patients on chronic hemodialysis

Maurizio Bossola, Enrico Di Stasio, Fausto Rosa, Loredana Dominici, Manuela Antocicco, Costanza Pazzaglia, Irene Aprile, Luigi Tazza

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Appetite in patients on chronic hemodialysis (HD) may be constantly very good/good or fair/poor or may fluctuate up and down over time. When constantly fair/poor, appetite has been shown to be associated with older age, more comorbidities, and more hospitalizations; however, it is unknown if it predicts survival. The aim of the present study was to assess appetite monthly for 6 months in patients on chronic HD and to determine if the course of appetite over time predicts mortality. Methods: Ninety-two HD patients were evaluated at baseline for appetite, nutritional and inflammatory markers, comorbid conditions, and Charlson's comorbidity index. Appetite assessment was repeated monthly for 6 consecutive months. Survival in relation with the course of appetite over time was determined. Results: Appetite was constantly very good/good in 45 patients (Group 1), fair/poor/very poor in 30 (Group 2), and fluctuated in 17 (Group 3). Twenty-seven (29.3 %) patients died after a mean period of 28 ± 13 months. Overall, the mean survival time was 42.1 ± 1.2 months. For Groups 1, 2, and 3, the mean survival time was 46.1 ± 0.92, 37.9 ± 2.5, and 39.1 ± 3.7 months, respectively (p <0.0001). After multivariate logistic regression analysis, the course of appetite over time was not found to be an independent risk factor for mortality. Conclusions: The course of appetite over time does not seem to predict mortality in patients on chronic hemodialysis. Considering that the study included a relatively small number of patients, larger similar studies are desirable.

Original languageEnglish
Pages (from-to)1091-1096
Number of pages6
JournalInternational Urology and Nephrology
Volume45
Issue number4
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Appetite
  • Hemodialysis
  • Longitudinal
  • Risk of death

ASJC Scopus subject areas

  • Nephrology
  • Urology

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