Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions. A prospective randomised clinical study on 120 patients

G. M. Calori, L. Tagliabue, L. Gala, M. d'Imporzano, G. Peretti, W. Albisetti

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this prospective randomised clinical study was to compare the efficacy of recombinant bone morphogenetic protein 7 (rhBMP-7) and platelet-rich plasma (PRP) as bone-stimulating agents in the treatment of persistent fracture non-unions. One hundred and twenty patients were randomised into two treatment groups (group rhBMP-7 vs. group PRP). Sixty patients with sixty fracture non-unions were assigned to each group (median age: 44 years, range 19-65, for the rhBMP-7 group and 41 years, range 21-62, for the PRP group, respectively). In the rhBMP-7 group, there were 15 tibial non-unions, 10 femoral, 15 humeral, 12 ulnar, and 8 radial non-unions. In the PRP group, there were 19 tibial non-unions, 8 femoral, 16 humeral, 8 ulnar, and 9 radial non-unions. The median number of operations performed prior to our intervention was 2 (range 1-5) and 2 (range 1-5) with autologous bone graft being used in 23 and 21 cases for the rhBMP-7 and PRP groups, respectively. Both clinical and radiological union occurred in 52 (86.7%) cases of the rhBMP-7 group compared to 41 (68.3%) cases of the PRP group, with a lower median clinical and radiographic healing time observed in the rhBMP-7 group (3.5 months vs. 4 months and 8 months vs. 9 months, respectively). This study supports the view that in the treatment of persistent long bone non-unions, the application of rhBMP-7 as a bone-stimulating agent is superior compared to that of PRP with regard to their clinical and radiological efficacy.

Original languageEnglish
Pages (from-to)1391-1402
Number of pages12
JournalInjury
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Bone healing
  • Long bones
  • Non-union
  • PRP
  • rhBMP-7

ASJC Scopus subject areas

  • Emergency Medicine
  • Orthopedics and Sports Medicine

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