Application of the GRADE Approach in the Development of Guidelines and Recommendations in Genomic Medicine

Muhammad Rafiq, Stefania Boccia

Research output: Contribution to journalArticle

Abstract

A great deal of ambiguity exists in the development of guidelines for genomic applications used in clinical practice. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach has the potential to be applied in the guidelines and recommendations development process in genomics. Here, we discuss whether and how GRADE can be applied to address the challenges posed by the evidence-based guidelines and recommendations development process in genomics. To see how GRADE can complement to the current guidelines development in genomics, we compare and contrast GRADE with other approaches. GRADE differed from other methods by incorporating patient values and preferences and balance of consequences. We conclude that the groups trying to implement genomics into practice may gleam more information from applying the GRADE framework. However, it is not clear yet whether GRADE can address the issue of timeliness in terms of the differences between the time required for guidelines development and the rapid pace of genomics.

Original languageEnglish
JournalGenomics Insights
Volume11
DOIs
Publication statusPublished - Jan 29 2018

Keywords

  • evidence-based guidelines
  • Genomic applications
  • genomic medicine
  • GRADE approach

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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