Application of the Intermediate-Stage Subclassification to Patients with Untreated Hepatocellular Carcinoma

Edoardo G. Giannini, Alessandro Moscatelli, Gaia Pellegatta, Alessandro Vitale, Fabio Farinati, Francesca Ciccarese, Fabio Piscaglia, Gian Lodovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Franco Borzio, Giuseppe Cabibbo, Martina Felder, Rodolfo Sacco, Filomena Morisco, Gabriele Missale, Francesco Giuseppe Foschi, Antonio Gasbarrini, Gianluca Svegliati BaroniRoberto Virdone, Alberto Masotto, Franco Trevisani, Luigi Bolondi, Maurizio Biselli, Paolo Caraceni, Alessandro Cucchetti, Marco Domenicali, Annagiulia Gramenzi, Donatella Magalotti, Anna Pecorelli, Carla Serra, Laura Venerandi, Alessia Gazzola, Francesca Murer, Caterina Pozzan, Veronica Vanin, Paolo Del Poggio, Stefano Olmi, Claudia Balsamo, Elena Vavassori, Luisa Benvegnù, Alberta Capelli, Rita Golfieri, Cristina Mosconi, Matteo Renzulli, Giulia Bosco, Paola Roselli, Serena Dell'Isola, Anna Maria Ialungo, Elena Rastrelli, Antonino Picciotto, Vincenzo Savarino, Andrea Mega, Emanuele Rinninella, Valeria Mismas, Arianna Lanzi, Federica Mirici Cappa, Alessandro Musetto, Elga Neri, Giuseppe Francesco Stefanini, Alessandra Suzzi, Stefano Tamberi, Omero Triossi, Maria Chiaramonte, Fabiana Marchetti, Matteo Valerio

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTIVES:The Barcelona Clinic Liver Cancer (BCLC) intermediate stage (BCLC B) includes a heterogeneous population of patients with hepatocellular carcinoma (HCC). Recently, in order to facilitate treatment decisions, a panel of experts proposed to subclassify BCLC B patients. In this study, we aimed to assess the prognostic capability of the BCLC B stage reclassification in a large cohort of patients with untreated HCC managed by the Italian Liver Cancer Group.METHODS:We assessed the prognosis of 269 untreated HCC patients observed in the period 1987-2012 who were reclassified according to the proposed subclassification of the BCLC B stage from stage B1 to stage B4. We evaluated and compared the survival of the various substages.RESULTS:Median survival progressively decreased from stage B1 (n=65, 24.2%: 25 months) through stages B2 (n=105, 39.0%: 16 months) and B3 (n=22, 8.2%: 9 months), to stage B4 (n=77, 28.6%: 5 months; P

Original languageEnglish
Pages (from-to)70-77
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume111
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Liver Neoplasms
Hepatocellular Carcinoma
Survival
Population

ASJC Scopus subject areas

  • Gastroenterology

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Application of the Intermediate-Stage Subclassification to Patients with Untreated Hepatocellular Carcinoma. / Giannini, Edoardo G.; Moscatelli, Alessandro; Pellegatta, Gaia; Vitale, Alessandro; Farinati, Fabio; Ciccarese, Francesca; Piscaglia, Fabio; Rapaccini, Gian Lodovico; Di Marco, Maria; Caturelli, Eugenio; Zoli, Marco; Borzio, Franco; Cabibbo, Giuseppe; Felder, Martina; Sacco, Rodolfo; Morisco, Filomena; Missale, Gabriele; Foschi, Francesco Giuseppe; Gasbarrini, Antonio; Baroni, Gianluca Svegliati; Virdone, Roberto; Masotto, Alberto; Trevisani, Franco; Bolondi, Luigi; Biselli, Maurizio; Caraceni, Paolo; Cucchetti, Alessandro; Domenicali, Marco; Gramenzi, Annagiulia; Magalotti, Donatella; Pecorelli, Anna; Serra, Carla; Venerandi, Laura; Gazzola, Alessia; Murer, Francesca; Pozzan, Caterina; Vanin, Veronica; Del Poggio, Paolo; Olmi, Stefano; Balsamo, Claudia; Vavassori, Elena; Benvegnù, Luisa; Capelli, Alberta; Golfieri, Rita; Mosconi, Cristina; Renzulli, Matteo; Bosco, Giulia; Roselli, Paola; Dell'Isola, Serena; Maria Ialungo, Anna; Rastrelli, Elena; Picciotto, Antonino; Savarino, Vincenzo; Mega, Andrea; Rinninella, Emanuele; Mismas, Valeria; Lanzi, Arianna; Cappa, Federica Mirici; Musetto, Alessandro; Neri, Elga; Stefanini, Giuseppe Francesco; Suzzi, Alessandra; Tamberi, Stefano; Triossi, Omero; Chiaramonte, Maria; Marchetti, Fabiana; Valerio, Matteo.

In: American Journal of Gastroenterology, Vol. 111, No. 1, 01.01.2016, p. 70-77.

Research output: Contribution to journalArticle

Giannini, EG, Moscatelli, A, Pellegatta, G, Vitale, A, Farinati, F, Ciccarese, F, Piscaglia, F, Rapaccini, GL, Di Marco, M, Caturelli, E, Zoli, M, Borzio, F, Cabibbo, G, Felder, M, Sacco, R, Morisco, F, Missale, G, Foschi, FG, Gasbarrini, A, Baroni, GS, Virdone, R, Masotto, A, Trevisani, F, Bolondi, L, Biselli, M, Caraceni, P, Cucchetti, A, Domenicali, M, Gramenzi, A, Magalotti, D, Pecorelli, A, Serra, C, Venerandi, L, Gazzola, A, Murer, F, Pozzan, C, Vanin, V, Del Poggio, P, Olmi, S, Balsamo, C, Vavassori, E, Benvegnù, L, Capelli, A, Golfieri, R, Mosconi, C, Renzulli, M, Bosco, G, Roselli, P, Dell'Isola, S, Maria Ialungo, A, Rastrelli, E, Picciotto, A, Savarino, V, Mega, A, Rinninella, E, Mismas, V, Lanzi, A, Cappa, FM, Musetto, A, Neri, E, Stefanini, GF, Suzzi, A, Tamberi, S, Triossi, O, Chiaramonte, M, Marchetti, F & Valerio, M 2016, 'Application of the Intermediate-Stage Subclassification to Patients with Untreated Hepatocellular Carcinoma', American Journal of Gastroenterology, vol. 111, no. 1, pp. 70-77. https://doi.org/10.1038/ajg.2015.389
Giannini, Edoardo G. ; Moscatelli, Alessandro ; Pellegatta, Gaia ; Vitale, Alessandro ; Farinati, Fabio ; Ciccarese, Francesca ; Piscaglia, Fabio ; Rapaccini, Gian Lodovico ; Di Marco, Maria ; Caturelli, Eugenio ; Zoli, Marco ; Borzio, Franco ; Cabibbo, Giuseppe ; Felder, Martina ; Sacco, Rodolfo ; Morisco, Filomena ; Missale, Gabriele ; Foschi, Francesco Giuseppe ; Gasbarrini, Antonio ; Baroni, Gianluca Svegliati ; Virdone, Roberto ; Masotto, Alberto ; Trevisani, Franco ; Bolondi, Luigi ; Biselli, Maurizio ; Caraceni, Paolo ; Cucchetti, Alessandro ; Domenicali, Marco ; Gramenzi, Annagiulia ; Magalotti, Donatella ; Pecorelli, Anna ; Serra, Carla ; Venerandi, Laura ; Gazzola, Alessia ; Murer, Francesca ; Pozzan, Caterina ; Vanin, Veronica ; Del Poggio, Paolo ; Olmi, Stefano ; Balsamo, Claudia ; Vavassori, Elena ; Benvegnù, Luisa ; Capelli, Alberta ; Golfieri, Rita ; Mosconi, Cristina ; Renzulli, Matteo ; Bosco, Giulia ; Roselli, Paola ; Dell'Isola, Serena ; Maria Ialungo, Anna ; Rastrelli, Elena ; Picciotto, Antonino ; Savarino, Vincenzo ; Mega, Andrea ; Rinninella, Emanuele ; Mismas, Valeria ; Lanzi, Arianna ; Cappa, Federica Mirici ; Musetto, Alessandro ; Neri, Elga ; Stefanini, Giuseppe Francesco ; Suzzi, Alessandra ; Tamberi, Stefano ; Triossi, Omero ; Chiaramonte, Maria ; Marchetti, Fabiana ; Valerio, Matteo. / Application of the Intermediate-Stage Subclassification to Patients with Untreated Hepatocellular Carcinoma. In: American Journal of Gastroenterology. 2016 ; Vol. 111, No. 1. pp. 70-77.
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AU - Giannini, Edoardo G.

AU - Moscatelli, Alessandro

AU - Pellegatta, Gaia

AU - Vitale, Alessandro

AU - Farinati, Fabio

AU - Ciccarese, Francesca

AU - Piscaglia, Fabio

AU - Rapaccini, Gian Lodovico

AU - Di Marco, Maria

AU - Caturelli, Eugenio

AU - Zoli, Marco

AU - Borzio, Franco

AU - Cabibbo, Giuseppe

AU - Felder, Martina

AU - Sacco, Rodolfo

AU - Morisco, Filomena

AU - Missale, Gabriele

AU - Foschi, Francesco Giuseppe

AU - Gasbarrini, Antonio

AU - Baroni, Gianluca Svegliati

AU - Virdone, Roberto

AU - Masotto, Alberto

AU - Trevisani, Franco

AU - Bolondi, Luigi

AU - Biselli, Maurizio

AU - Caraceni, Paolo

AU - Cucchetti, Alessandro

AU - Domenicali, Marco

AU - Gramenzi, Annagiulia

AU - Magalotti, Donatella

AU - Pecorelli, Anna

AU - Serra, Carla

AU - Venerandi, Laura

AU - Gazzola, Alessia

AU - Murer, Francesca

AU - Pozzan, Caterina

AU - Vanin, Veronica

AU - Del Poggio, Paolo

AU - Olmi, Stefano

AU - Balsamo, Claudia

AU - Vavassori, Elena

AU - Benvegnù, Luisa

AU - Capelli, Alberta

AU - Golfieri, Rita

AU - Mosconi, Cristina

AU - Renzulli, Matteo

AU - Bosco, Giulia

AU - Roselli, Paola

AU - Dell'Isola, Serena

AU - Maria Ialungo, Anna

AU - Rastrelli, Elena

AU - Picciotto, Antonino

AU - Savarino, Vincenzo

AU - Mega, Andrea

AU - Rinninella, Emanuele

AU - Mismas, Valeria

AU - Lanzi, Arianna

AU - Cappa, Federica Mirici

AU - Musetto, Alessandro

AU - Neri, Elga

AU - Stefanini, Giuseppe Francesco

AU - Suzzi, Alessandra

AU - Tamberi, Stefano

AU - Triossi, Omero

AU - Chiaramonte, Maria

AU - Marchetti, Fabiana

AU - Valerio, Matteo

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