Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors

Francesco Prada, M. Yashar S. Kalani, Kaan Yagmurlu, Pedro Norat, Massimiliano Del Bene, Francesco DiMeco, Neal F. Kassell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Oncology and cerebrovascular disease constitute two of the most common diseases afflicting the central nervous system. Standard of treatment of these pathologies is based on multidisciplinary approaches encompassing combination of interventional procedures such as open and endovascular surgeries, drugs (chemotherapies, anti-coagulants, anti-platelet therapies, thrombolytics), and radiation therapies. In this context, therapeutic ultrasound could represent a novel diagnostic/therapeutic in the armamentarium of the surgeon to treat these diseases. Ultrasound relies on mechanical energy to induce numerous physical and biological effects. The application of this technology in neurology has been limited due to the challenges with penetrating the skull, thus limiting a prompt translation as has been seen in treating pathologies in other organs, such as breast and abdomen. Thanks to pivotal adjuncts such as multiconvergent transducers, magnetic resonance imaging (MRI) guidance, MRI thermometry, implantable transducers, and acoustic windows, focused ultrasound (FUS) is ready for prime-time applications in oncology and cerebrovascular neurology. In this review, we analyze the evolution of FUS from the beginning in 1950s to current state-of-the-art. We provide an overall picture of actual and future applications of FUS in oncology and cerebrovascular neurology reporting for each application the principal existing evidences.

Original languageEnglish
JournalNeurotherapeutics
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Cerebrovascular Disorders
Brain Neoplasms
Neurology
Transducers
Magnetic Resonance Imaging
Thermometry
Pathology
Coagulants
Central Nervous System Diseases
Thrombolytic Therapy
Therapeutics
Acoustics
Skull
Abdomen
Breast
Radiotherapy
Blood Platelets
Technology
Drug Therapy
Pharmaceutical Preparations

Keywords

  • cerebrovascular neurology
  • focused ultrasound
  • Neuro-oncology
  • neurosurgery
  • therapeutic ultrasound

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors. / Prada, Francesco; Kalani, M. Yashar S.; Yagmurlu, Kaan; Norat, Pedro; Del Bene, Massimiliano; DiMeco, Francesco; Kassell, Neal F.

In: Neurotherapeutics, 01.01.2018.

Research output: Contribution to journalArticle

Prada, Francesco ; Kalani, M. Yashar S. ; Yagmurlu, Kaan ; Norat, Pedro ; Del Bene, Massimiliano ; DiMeco, Francesco ; Kassell, Neal F. / Applications of Focused Ultrasound in Cerebrovascular Diseases and Brain Tumors. In: Neurotherapeutics. 2018.
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