TY - JOUR
T1 - Applications of genomics in NSCLC
AU - Rosell, Rafael
AU - Cobo, Manuel
AU - Isla, Dolores
AU - Miguel Sanchez, Jose
AU - Taron, Miquel
AU - Altavilla, Giuseppe
AU - Santarpia, Mariacarmela
AU - Moran, Teresa
AU - Catot, Silvia
AU - Etxaniz, Olatz
PY - 2005/12
Y1 - 2005/12
N2 - Cisplatin-based chemotherapy has long been the cornerstone of non-small cell lung cancer (NSCLC) management. However, median survival rarely exceeds 1 year. The identification of molecular markers can help to predict response, leading to a broad implementation of the new concept of customized chemotherapy. ERCC1 is an excision nuclease within the nucleotide excision repair pathway that forms a heterodimer with XPE As a unit, they execute the 5′ incision into the DNA strand relative to the site of DNA damage. The 5′ excision is the last of several steps that are specific to excision of a platinum DNA lesion. In mouse models, normal ERCC1 function is critical to normal aging and brain development. Numerous studies indicate that ERCC1 influences the repair of platinum DNA damage. We report here our accumulated experience of ERCC1 mRNA expression and outcome in cisplatin-treated NSCLC patients and the preliminary confirmatory data on a prospective ERCC1 mRNA customized docetaxel-cisplatin trial, in which low ERCC1 mRNA levels in the tumor correlate with significantly better response. ERCC1 is one of several proteins involved in the repairosome, where other DNA repair genes, such as BRCA1, are also central to cisplatin resistance.
AB - Cisplatin-based chemotherapy has long been the cornerstone of non-small cell lung cancer (NSCLC) management. However, median survival rarely exceeds 1 year. The identification of molecular markers can help to predict response, leading to a broad implementation of the new concept of customized chemotherapy. ERCC1 is an excision nuclease within the nucleotide excision repair pathway that forms a heterodimer with XPE As a unit, they execute the 5′ incision into the DNA strand relative to the site of DNA damage. The 5′ excision is the last of several steps that are specific to excision of a platinum DNA lesion. In mouse models, normal ERCC1 function is critical to normal aging and brain development. Numerous studies indicate that ERCC1 influences the repair of platinum DNA damage. We report here our accumulated experience of ERCC1 mRNA expression and outcome in cisplatin-treated NSCLC patients and the preliminary confirmatory data on a prospective ERCC1 mRNA customized docetaxel-cisplatin trial, in which low ERCC1 mRNA levels in the tumor correlate with significantly better response. ERCC1 is one of several proteins involved in the repairosome, where other DNA repair genes, such as BRCA1, are also central to cisplatin resistance.
KW - Cisplatin
KW - DNA repair genes
KW - Docetaxel
KW - ERCC1
KW - Genomics
KW - Non-small cell lung cancer
UR - http://www.scopus.com/inward/record.url?scp=33645030839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645030839&partnerID=8YFLogxK
U2 - 10.1016/S0169-5002(05)81571-5
DO - 10.1016/S0169-5002(05)81571-5
M3 - Article
C2 - 16557672
AN - SCOPUS:33645030839
VL - 50
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - SUPPL. 2
ER -