Applications of Surface Plasmon Resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes

Mara Canovi, Jacopo Lucchetti, Matteo Stravalaci, Francesca Re, Davide Moscatelli, Paolo Bigini, Mario Salmona, Marco Gobbi

Research output: Contribution to journalArticlepeer-review

Abstract

Great interest is currently being devoted to the development of nanoparticles (NPs) for biomedical purposes, designed to improve the pharmacokinetic profile of their cargos (either imaging probes or drugs) and to enhance the specific targeting at the disease site. Recent works suggest that Surface Plasmon Resonance (SPR), widely used for the analysis of biomolecular interactions, represents a technique of choice for rapid and quantitative analyses of the interaction between NPs-functionalized with specific ligands-and their putative biological targets. Moreover, SPR can provide important details on the formation and the role of the protein 'corona', i.e., the protein layer which coats NPs once they come into contact with biological fluids. These novel applications of SPR sensors may be very useful to characterize, screen and develop nanodevices for biomedical purposes.

Original languageEnglish
Pages (from-to)16420-16432
Number of pages13
JournalSensors (Switzerland)
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Nanoparticles
  • Protein corona
  • Surface plasmon resonance

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Analytical Chemistry
  • Biochemistry

Fingerprint Dive into the research topics of 'Applications of Surface Plasmon Resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes'. Together they form a unique fingerprint.

Cite this