Applying multilevel model to the relationship of dietary patterns and colorectal cancer: An ongoing case-control study in Córdoba, Argentina

Sonia Alejandra Pou, María Del Pilar Díaz, Alberto Rubén Osella

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purposes: Scientific literature has consistently shown the effects of certain diets on health but regional variations of dietary habits, and their relationship colorectal cancer (CRC) has been poorly studied in Argentina. Our aims were to identify dietary patterns and estimate their effect on CRC occurrence and to quantify the association between family history of CRC and CRC occurrence by applying multilevel models to estimate and interpret measures of variation. Methods: Principal components factor analysis was performed to identify dietary patterns that were then used in a multilevel logistic regression applied to an ongoing case-control data about dietary exposure and CRC occurrence taking into account familiar clustering. Results: Three dietary patterns were identified: "Southern Cone pattern" (red meat, wine, and starchy vegetables), "High-sugar drinks pattern", and "Prudent pattern". The study considered 41 cases and 95 controls. There was a significant promoting effects on CRC of "Southern Cone" (OR 1.5, 95%CI 1.0-2.2) and "High-sugar drinks" (OR 3.8, 95%CI 2.0-7.1) patterns, whereas "Prudent pattern" (OR 0.3, 95%CI 0.2-0.4) showed a significant protective effect at third tertile level. BMI, use of NSAIDs, and to have medical insurance showed significant effects. Variance of the random effect of family history of CRC was highly significant. Conclusions: This novel approach for Argentina showed that Southern Cone and High-sugar drinks patterns were associated with a higher risk of CRC, whereas the Prudent pattern showed a protective effect. There was a significant clustering effect of family history of CRC.

Original languageEnglish
Pages (from-to)755-764
Number of pages10
JournalEuropean Journal of Nutrition
Volume51
Issue number6
DOIs
Publication statusPublished - Sep 2012

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Argentina
Case-Control Studies
Colorectal Neoplasms
Cluster Analysis
Literature
Non-Steroidal Anti-Inflammatory Agents
Feeding Behavior
Wine
Principal Component Analysis
Insurance
Vegetables
Statistical Factor Analysis
Logistic Models
Diet
Health

Keywords

  • Argentina
  • Colorectal cancer
  • Dietary patterns
  • Meat intake
  • Multilevel

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Applying multilevel model to the relationship of dietary patterns and colorectal cancer : An ongoing case-control study in Córdoba, Argentina. / Pou, Sonia Alejandra; Díaz, María Del Pilar; Osella, Alberto Rubén.

In: European Journal of Nutrition, Vol. 51, No. 6, 09.2012, p. 755-764.

Research output: Contribution to journalArticle

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