Applying proteomic technology to clinical virology

Research output: Contribution to journalArticlepeer-review

Abstract

Developing antiviral drugs, vaccines and diagnostic markers is still the most ambitious challenge in clinical virology. In the past few decades, data from high-throughput technologies have allowed for the rapid development of new antiviral therapeutic strategies, thus making a profound impact on translational research. Most of the current preclinical studies in virology are aimed at evaluating the dynamic composition and localization of the protein platforms involved in various host-virus interactions. Among the different possible approaches, mass spectrometry-based proteomics is increasingly being used to define the protein composition in subcellular compartments, quantify differential protein expression among samples, characterize protein complexes, and analyse protein post-translational modifications. Here, we review the current knowledge of the most useful proteomic approaches in the study of viral persistence and pathogenicity, with a particular focus on recent advances in hepatitis C research.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalClinical Microbiology and Infection
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Biomarker discovery
  • HCV
  • Mass spectrometry
  • Post-translational modifications
  • Proteomics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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