Approaches for the design and evaluation of HIV-1 DNA vaccines

Sandra A. Calarota, David B. Weiner

Research output: Contribution to journalArticle

Abstract

Although it is not clear what arm of the immune response correlates with protection from HIV-1 infection or disease, a robust broad cellular and humoral immune response will likely be needed to control this infection. Accordingly, it is crucial to characterize which HIV-1 gene products are potential targets to elicit these responses. DNA vaccination has been shown to be effective for induction of both humoral and cellular immune responses in animal models. Most DNA vaccine strategies studied to date have been based on targeting structural HIV-1 proteins, but others have focused on the regulatory/accessory HIV-1 proteins as an approach to induce immune responses able to recognize early infected cells. It has also become clear that HIV-DNA vaccine efficacy in humans requires improvement. Combinations of HIV-1 genes, improvement of the DNA vector itself, or addition of genetic adjuvants (cytokines or costimulatory molecules) as part of the DNA vaccine itself, have been evaluated by several groups as approaches for enhancing DNA vaccine-induced immune responses. Encouraging results have been obtained in primate models, supporting that these strategies should be further evaluated in humans, for either prophylaxis or immune therapy of HIV-1.

Original languageEnglish
JournalExpert Review of Vaccines
Volume3
Issue number4 SUPPL.
DOIs
Publication statusPublished - Aug 2004

Fingerprint

DNA Vaccines
HIV-1
Human Immunodeficiency Virus Proteins
Humoral Immunity
Cellular Immunity
AIDS Vaccines
DNA
Infection Control
Primates
HIV Infections
Vaccination
Animal Models
Cytokines
Genes

Keywords

  • Costimulatory molecules
  • Cytokine genes
  • DNA vaccines
  • HIV-1
  • Immune responses
  • Regulatory genes
  • Structural genes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Approaches for the design and evaluation of HIV-1 DNA vaccines. / Calarota, Sandra A.; Weiner, David B.

In: Expert Review of Vaccines, Vol. 3, No. 4 SUPPL., 08.2004.

Research output: Contribution to journalArticle

Calarota, Sandra A. ; Weiner, David B. / Approaches for the design and evaluation of HIV-1 DNA vaccines. In: Expert Review of Vaccines. 2004 ; Vol. 3, No. 4 SUPPL.
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