Approaching low liver iron burden in chelated patients with non-transfusion-dependent thalassemia: The safety profile of deferasirox

Ali T. Taher, John B. Porter, Vip Viprakasit, Antonis Kattamis, Suporn Chuncharunee, Pranee Sutcharitchan, Noppadol Siritanaratkul, Raffaella Origa, Zeynep Karakas, Dany Habr, Zewen Zhu, M. Domenica Cappellini

Research output: Contribution to journalArticle

Abstract

Objective: Patients with non-transfusion-dependent thalassemia (NTDT) often develop iron overload and related complications, and may require iron chelation. However, the risk of over-chelation emerges as patients reach low, near-normal body iron levels and dose adjustments may be needed. In the THALASSA study, the threshold for chelation interruption was LIC

Original languageEnglish
Pages (from-to)521-526
Number of pages6
JournalEuropean Journal of Haematology
Volume92
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Iron chelation
  • Iron overload
  • Thalassemia

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Taher, A. T., Porter, J. B., Viprakasit, V., Kattamis, A., Chuncharunee, S., Sutcharitchan, P., Siritanaratkul, N., Origa, R., Karakas, Z., Habr, D., Zhu, Z., & Cappellini, M. D. (2014). Approaching low liver iron burden in chelated patients with non-transfusion-dependent thalassemia: The safety profile of deferasirox. European Journal of Haematology, 92(6), 521-526. https://doi.org/10.1111/ejh.12270