Aprotinin inhibits the hormone binding of the estrogen receptor from calf uterus

Vincenzo Nigro, Nicola Medici, Ciro Abbondanza, Saverio Minucci, Anna Maria Molinari, Giovanni Alfredo Puca

Research output: Contribution to journalArticle

Abstract

Micromolar concentrations of the proteinase inhibitor, aprotinin, produced a dose-dependent inhibition in the binding capacity of the estrogen receptor from calf uterus. Aprotinin inhibition was greater at 28°C than at 4°C and only occurred when conditions allowed the receptor transformation. When aprotinin was tested in the presence of transformation inhibitors, its effect was no longer seen. The binding capacity of the highly purified estrogen-binding subunit was similarly inhibited.

Original languageEnglish
Pages (from-to)1206-1211
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume164
Issue number3
DOIs
Publication statusPublished - Nov 15 1989

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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