Aquaporin 2 and Apical Calcium-Sensing Receptor

New Players in Polyuric Disorders Associated With Hypercalciuria

G. Procino, L. Mastrofrancesco, A. Mira, G. Tamma, M. Carmosino, F. Emma, M. Svelto, G. Valenti

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The kidney plays a critical role in regulating water homeostasis through specific proteins highly expressed in the kidney, called aquaporins, allowing water permeation at a high rate. This brief review focuses on some nephropathies associated with impaired urinary concentrating ability and in particular analyzes the role of aquaporin 2 in hypercalciuria, the most common metabolic abnormality in patients with nephrolithiasis. Specifically, this review discusses the relationship between hypercalciuria and impaired aquaporin 2-mediated water handling in both acquired and inherited disorders characterized by hypercalciuria, including those affecting the sensor of extracellular calcium concentration, the calcium-sensing receptor, which represents the principal target for extracellular calcium regulation of several tissues including parathyroid glands and kidney. In the kidney, the calcium-sensing receptor regulates renal calcium excretion and influences the transepithelial movement of water and other electrolytes. Understanding the molecular basis of alteration of kidney concentrating ability found in hypercalciuria will help for devising strategies for reducing the risk of nephrocalcinosis, nephrolithiasis, and renal insufficiency.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalSeminars in Nephrology
Volume28
Issue number3
DOIs
Publication statusPublished - May 2008

Fingerprint

Aquaporin 2
Calcium-Sensing Receptors
Hypercalciuria
Kidney
Nephrolithiasis
Calcium
Water
Kidney Concentrating Ability
Nephrocalcinosis
Water Movements
Aquaporins
Parathyroid Glands
Electrolytes
Renal Insufficiency
Homeostasis
Proteins

Keywords

  • ADH
  • aquaporin
  • calcilytic drugs
  • Calcium sensing receptor
  • nephrolithiasis
  • stones

ASJC Scopus subject areas

  • Nephrology

Cite this

Aquaporin 2 and Apical Calcium-Sensing Receptor : New Players in Polyuric Disorders Associated With Hypercalciuria. / Procino, G.; Mastrofrancesco, L.; Mira, A.; Tamma, G.; Carmosino, M.; Emma, F.; Svelto, M.; Valenti, G.

In: Seminars in Nephrology, Vol. 28, No. 3, 05.2008, p. 297-305.

Research output: Contribution to journalArticle

Procino, G, Mastrofrancesco, L, Mira, A, Tamma, G, Carmosino, M, Emma, F, Svelto, M & Valenti, G 2008, 'Aquaporin 2 and Apical Calcium-Sensing Receptor: New Players in Polyuric Disorders Associated With Hypercalciuria', Seminars in Nephrology, vol. 28, no. 3, pp. 297-305. https://doi.org/10.1016/j.semnephrol.2008.03.007
Procino, G. ; Mastrofrancesco, L. ; Mira, A. ; Tamma, G. ; Carmosino, M. ; Emma, F. ; Svelto, M. ; Valenti, G. / Aquaporin 2 and Apical Calcium-Sensing Receptor : New Players in Polyuric Disorders Associated With Hypercalciuria. In: Seminars in Nephrology. 2008 ; Vol. 28, No. 3. pp. 297-305.
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