TY - JOUR
T1 - Aquaporins in cancer
AU - Ribatti, Domenico
AU - Ranieri, Girolamo
AU - Annese, Tiziana
AU - Nico, Beatrice
PY - 2014
Y1 - 2014
N2 - Background The aquaporins (AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement, transport of fluid and cell migration. Scope of the review This review article summarizes our knowledge concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process. Major conclusions Tumor cells types express AQPs and a positive correlation exists between histological tumor grade and the AQP expression. Moreover, AQPs are involved also in tumor edema formation and angiogenesis in several solid and hematological tumors. General significance AQPs inhibition in endothelial and tumor cells might limit tumor growth and spread, suggesting a potential therapeutic use in the treatment of tumors. This article is part of a Special Issue entitled Aquaporins.
AB - Background The aquaporins (AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement, transport of fluid and cell migration. Scope of the review This review article summarizes our knowledge concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process. Major conclusions Tumor cells types express AQPs and a positive correlation exists between histological tumor grade and the AQP expression. Moreover, AQPs are involved also in tumor edema formation and angiogenesis in several solid and hematological tumors. General significance AQPs inhibition in endothelial and tumor cells might limit tumor growth and spread, suggesting a potential therapeutic use in the treatment of tumors. This article is part of a Special Issue entitled Aquaporins.
KW - Angiogenesis
KW - Aquaporins
KW - Edema
KW - Glioblastoma
KW - Tumor growth
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U2 - 10.1016/j.bbagen.2013.09.025
DO - 10.1016/j.bbagen.2013.09.025
M3 - Article
C2 - 24064112
AN - SCOPUS:84897114781
VL - 1840
SP - 1550
EP - 1553
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
SN - 0304-4165
IS - 5
ER -