Aquaporins in cancer

Domenico Ribatti, Girolamo Ranieri, Tiziana Annese, Beatrice Nico

Research output: Contribution to journalArticle

Abstract

Background The aquaporins (AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement, transport of fluid and cell migration. Scope of the review This review article summarizes our knowledge concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process. Major conclusions Tumor cells types express AQPs and a positive correlation exists between histological tumor grade and the AQP expression. Moreover, AQPs are involved also in tumor edema formation and angiogenesis in several solid and hematological tumors. General significance AQPs inhibition in endothelial and tumor cells might limit tumor growth and spread, suggesting a potential therapeutic use in the treatment of tumors. This article is part of a Special Issue entitled Aquaporins.

Original languageEnglish
Pages (from-to)1550-1553
Number of pages4
JournalBBA - General Subjects
Volume1840
Issue number5
DOIs
Publication statusPublished - 2014

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Keywords

  • Angiogenesis
  • Aquaporins
  • Edema
  • Glioblastoma
  • Tumor growth

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Ribatti, D., Ranieri, G., Annese, T., & Nico, B. (2014). Aquaporins in cancer. BBA - General Subjects, 1840(5), 1550-1553. https://doi.org/10.1016/j.bbagen.2013.09.025