Aquaporins in tumor growth and angiogenesis

Beatrice Nico, Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

The aquaporins (AQPs) are a family of transmembrane water channel proteins widely distributed and play a major role in transcellular and transepithelial water movement. Moreover, recent evidence indicates that AQPs may be involved in cell migration and angiogenesis. This review article summarizes literature data concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process and suggest a potential therapeutic approach by antagonizing their biological activity.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalCancer Letters
Volume294
Issue number2
DOIs
Publication statusPublished - Aug 2010

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Keywords

  • Angiogenesis
  • Aquaporins
  • Metastastis
  • Tumor growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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