Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow

Clive B. Beggs, Christopher Magnano, Simon J. Shepherd, Karen Marr, Vesela Valnarov, David Hojnacki, Niels Bergsland, Pavel Belov, Steven Grisafi, Michael G. Dwyer, Ellen Carl, Bianca Weinstock-Guttman, Robert Zivadinov

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Results: CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVInegative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021).

Conclusion: CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals.

Materials and Methods: Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled ≥2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes.

Purpose: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and - negative healthy individuals using cine phase contrast imaging.

Original languageEnglish
Pages (from-to)1215-1222
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number5
DOIs
Publication statusPublished - Nov 1 2014

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Venous Insufficiency
Cerebrospinal Fluid
Cerebral Aqueduct
Doppler Ultrasonography
Hydrodynamics
Hemodynamics

Keywords

  • Aqueduct of Sylvius
  • CCSVI
  • Cerebral venous outflow
  • CSF dynamics
  • Healthy individuals
  • Lateral ventricle volume

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Beggs, C. B., Magnano, C., Shepherd, S. J., Marr, K., Valnarov, V., Hojnacki, D., ... Zivadinov, R. (2014). Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. Journal of Magnetic Resonance Imaging, 40(5), 1215-1222. https://doi.org/10.1002/jmri.24468

Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. / Beggs, Clive B.; Magnano, Christopher; Shepherd, Simon J.; Marr, Karen; Valnarov, Vesela; Hojnacki, David; Bergsland, Niels; Belov, Pavel; Grisafi, Steven; Dwyer, Michael G.; Carl, Ellen; Weinstock-Guttman, Bianca; Zivadinov, Robert.

In: Journal of Magnetic Resonance Imaging, Vol. 40, No. 5, 01.11.2014, p. 1215-1222.

Research output: Contribution to journalArticle

Beggs, CB, Magnano, C, Shepherd, SJ, Marr, K, Valnarov, V, Hojnacki, D, Bergsland, N, Belov, P, Grisafi, S, Dwyer, MG, Carl, E, Weinstock-Guttman, B & Zivadinov, R 2014, 'Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow', Journal of Magnetic Resonance Imaging, vol. 40, no. 5, pp. 1215-1222. https://doi.org/10.1002/jmri.24468
Beggs, Clive B. ; Magnano, Christopher ; Shepherd, Simon J. ; Marr, Karen ; Valnarov, Vesela ; Hojnacki, David ; Bergsland, Niels ; Belov, Pavel ; Grisafi, Steven ; Dwyer, Michael G. ; Carl, Ellen ; Weinstock-Guttman, Bianca ; Zivadinov, Robert. / Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. In: Journal of Magnetic Resonance Imaging. 2014 ; Vol. 40, No. 5. pp. 1215-1222.
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AU - Magnano, Christopher

AU - Shepherd, Simon J.

AU - Marr, Karen

AU - Valnarov, Vesela

AU - Hojnacki, David

AU - Bergsland, Niels

AU - Belov, Pavel

AU - Grisafi, Steven

AU - Dwyer, Michael G.

AU - Carl, Ellen

AU - Weinstock-Guttman, Bianca

AU - Zivadinov, Robert

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