Arachidonic acid induces human platelet-fibrin retraction: The role of platelet cyclic endoperoxides

Giovanni Di Minno, Vittorio Bertelé, Chiara Cerletti, Giovanni de Gaetano, Melvin J. Silver

Research output: Contribution to journalArticle

Abstract

Arachidonic acid (0.2-0.8 mM) retracts clots formed in human citrated platelet-rich plasma by batroxobin. Extracellular calcium ions, but not the secretion of ADP by platelets, are required. AA-induced clot-retraction requires cyclo-oxygenase but not thromboxane synthetase activity since the retraction is inhibited by aspirin but not by selective inhibitors of thromboxane synthesis. The data indicate that endogenous cyclic endoperoxides mediate the retraction. Moreover, intact endoperoxide/thromboxane receptors also seem to be necessary because clot retraction is inhibited by thromboxane receptor antagonists.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalThrombosis Research
Volume25
Issue number4
DOIs
Publication statusPublished - Feb 15 1982

Keywords

  • arachidonic acid metabolism
  • Clot retraction
  • platelets

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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