Arachidonic acid metabolic profiles in human meningiomas and gliomas

Maria Grazia Castellil, Giorgio Butti, Chiara Chiabrando, Elena Cozzi, Roberto Fanelli, Paolo Gaetani, Vittorio Silvani, Pietro Paoletti

Research output: Contribution to journalArticle

Abstract

We determined arachidonic acid (AA) cyclooxygenase metabolic profiles in specimens of human intracranial tumors (gliomas and meningiomas) and, when available, normal brain tissue. Samples were collected at surgery and immediately frozen in liquid nitrogen. The five stable metabolites of AA (PGE2, PGD2, PGF2α, 6-keto-PGF1α and TXB2) were measured by high-resolution gas chromatography-mass spectrometry after ex vivo metabolism of endogenous AA by tissue homogenates. The absolute amounts of AA metabolites varied widely between samples, though meningiomas and gliomas showed characteristic profiles. Compared to the slow-growing benign meningiomas, the rapidly-growing infiltrating gliomas had higher synthesis of TXA2 (reported as a procancer metabolite) and lower synthesis of PGD2 and PGI2 (reported as anticancer metabolites). A higher overall synthesis capacity, preferentially toward TXA2, was found in glioblastomas than in nonpathological brain tissue.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalJournal of Neuro-Oncology
Volume5
Issue number4
DOIs
Publication statusPublished - Dec 1987

Keywords

  • arachidonic acid metabolism
  • brain tumors
  • malignant gliomas
  • meningiomas
  • prostaglandins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Castellil, M. G., Butti, G., Chiabrando, C., Cozzi, E., Fanelli, R., Gaetani, P., Silvani, V., & Paoletti, P. (1987). Arachidonic acid metabolic profiles in human meningiomas and gliomas. Journal of Neuro-Oncology, 5(4), 369-375. https://doi.org/10.1007/BF00148394