The animal experiments confirm that high cholesterol levels in plasma may affect platelet aggregation, with a mechanism involving modification of platelet membrane function, inducing a hyperaggregability similar to that of platelets from human subjects with type II A hypercholesteremia. This effect may be counteracted or prevented by treatment with metformin, a drug which does not affect plasma cholesterol levels, but increases platelet membrane fluidity.
|Translated title of the contribution||Arachidonic acid metabolites in the interaction between platelets and arterial walls|
|Number of pages||4|
|Journal||Giornale della Arteriosclerosi|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine