Abstract
Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC). GM volume and cerebral blood flow (CBF) differences and their correlation were tested with a voxel-wise approach. Results MS patients (41.4±12.5 years; 14 females) had a median [25th-75th percentile range] Expanded Disability Status Scale of 1.0[1.0-2.4] and a median [25th - 75th percentile range] disease duration of 8.0 [4.0 - 16.5] years. HC were age- and sex-matched (43.9±17.4 years; 11 females). GM atrophy was detected for MS group in the right parahippocampal gyrus, thalami and left caudate (pFWE≤0.05). Areas of significant (after family wise error -FWE- correction for multiple comparisons) (pFWE≤0.05) hypoperfusion were found for MS in the anterior cingulate and paracingulate gyri, supplementary motor cortex, precentral and superior frontal gyrus. GM volume and CBF showed a significant correlation (pFWE≤0.05) in the right lateral occipital cortex and precuneus in the MS group. Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume.
| Original language | English |
|---|---|
| Journal | Current Neurovascular Research |
| DOIs | |
| Publication status | E-pub ahead of print - Nov 23 2018 |
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Are cerebral perfusion and atrophy linked in multiple sclerosis? Evidence for a multifactorial approach to assess neurodegeneration. / Laganà, Maria Marcella; Mendozzi, Laura; Pelizzari, Laura; Bergsland, Niels Peter; Pugnetti, Luigi; Cecconi, Pietro; Baselli, Giuseppe; Clerici, Mario; Nemni, Raffaello; Baglio, Francesca.
In: Current Neurovascular Research, 23.11.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Are cerebral perfusion and atrophy linked in multiple sclerosis?
T2 - Evidence for a multifactorial approach to assess neurodegeneration
AU - Laganà, Maria Marcella
AU - Mendozzi, Laura
AU - Pelizzari, Laura
AU - Bergsland, Niels Peter
AU - Pugnetti, Luigi
AU - Cecconi, Pietro
AU - Baselli, Giuseppe
AU - Clerici, Mario
AU - Nemni, Raffaello
AU - Baglio, Francesca
N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
PY - 2018/11/23
Y1 - 2018/11/23
N2 - Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC). GM volume and cerebral blood flow (CBF) differences and their correlation were tested with a voxel-wise approach. Results MS patients (41.4±12.5 years; 14 females) had a median [25th-75th percentile range] Expanded Disability Status Scale of 1.0[1.0-2.4] and a median [25th - 75th percentile range] disease duration of 8.0 [4.0 - 16.5] years. HC were age- and sex-matched (43.9±17.4 years; 11 females). GM atrophy was detected for MS group in the right parahippocampal gyrus, thalami and left caudate (pFWE≤0.05). Areas of significant (after family wise error -FWE- correction for multiple comparisons) (pFWE≤0.05) hypoperfusion were found for MS in the anterior cingulate and paracingulate gyri, supplementary motor cortex, precentral and superior frontal gyrus. GM volume and CBF showed a significant correlation (pFWE≤0.05) in the right lateral occipital cortex and precuneus in the MS group. Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume.
AB - Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC). GM volume and cerebral blood flow (CBF) differences and their correlation were tested with a voxel-wise approach. Results MS patients (41.4±12.5 years; 14 females) had a median [25th-75th percentile range] Expanded Disability Status Scale of 1.0[1.0-2.4] and a median [25th - 75th percentile range] disease duration of 8.0 [4.0 - 16.5] years. HC were age- and sex-matched (43.9±17.4 years; 11 females). GM atrophy was detected for MS group in the right parahippocampal gyrus, thalami and left caudate (pFWE≤0.05). Areas of significant (after family wise error -FWE- correction for multiple comparisons) (pFWE≤0.05) hypoperfusion were found for MS in the anterior cingulate and paracingulate gyri, supplementary motor cortex, precentral and superior frontal gyrus. GM volume and CBF showed a significant correlation (pFWE≤0.05) in the right lateral occipital cortex and precuneus in the MS group. Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume.
U2 - 10.2174/1567202616666181123164235
DO - 10.2174/1567202616666181123164235
M3 - Article
C2 - 30468125
JO - Current Neurovascular Research
JF - Current Neurovascular Research
SN - 1567-2026
ER -