Are cerebral perfusion and atrophy linked in multiple sclerosis? Evidence for a multifactorial approach to assess neurodegeneration

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Abstract

Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC). GM volume and cerebral blood flow (CBF) differences and their correlation were tested with a voxel-wise approach. Results MS patients (41.4±12.5 years; 14 females) had a median [25th-75th percentile range] Expanded Disability Status Scale of 1.0[1.0-2.4] and a median [25th - 75th percentile range] disease duration of 8.0 [4.0 - 16.5] years. HC were age- and sex-matched (43.9±17.4 years; 11 females). GM atrophy was detected for MS group in the right parahippocampal gyrus, thalami and left caudate (pFWE≤0.05). Areas of significant (after family wise error -FWE- correction for multiple comparisons) (pFWE≤0.05) hypoperfusion were found for MS in the anterior cingulate and paracingulate gyri, supplementary motor cortex, precentral and superior frontal gyrus. GM volume and CBF showed a significant correlation (pFWE≤0.05) in the right lateral occipital cortex and precuneus in the MS group. Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume.

Original languageEnglish
JournalCurrent Neurovascular Research
DOIs
Publication statusE-pub ahead of print - Nov 23 2018

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Multiple Sclerosis
Atrophy
Perfusion
Cerebrovascular Circulation
Relapsing-Remitting Multiple Sclerosis
Occipital Lobe
Parahippocampal Gyrus
Parietal Lobe
Gyrus Cinguli
Motor Cortex
Prefrontal Cortex
Thalamus
Gray Matter
Magnetic Resonance Imaging

Cite this

@article{fb6c32af25664e399d5dc9923d4839f7,
title = "Are cerebral perfusion and atrophy linked in multiple sclerosis?: Evidence for a multifactorial approach to assess neurodegeneration",
abstract = "Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC). GM volume and cerebral blood flow (CBF) differences and their correlation were tested with a voxel-wise approach. Results MS patients (41.4±12.5 years; 14 females) had a median [25th-75th percentile range] Expanded Disability Status Scale of 1.0[1.0-2.4] and a median [25th - 75th percentile range] disease duration of 8.0 [4.0 - 16.5] years. HC were age- and sex-matched (43.9±17.4 years; 11 females). GM atrophy was detected for MS group in the right parahippocampal gyrus, thalami and left caudate (pFWE≤0.05). Areas of significant (after family wise error -FWE- correction for multiple comparisons) (pFWE≤0.05) hypoperfusion were found for MS in the anterior cingulate and paracingulate gyri, supplementary motor cortex, precentral and superior frontal gyrus. GM volume and CBF showed a significant correlation (pFWE≤0.05) in the right lateral occipital cortex and precuneus in the MS group. Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume.",
author = "Lagan{\`a}, {Maria Marcella} and Laura Mendozzi and Laura Pelizzari and Bergsland, {Niels Peter} and Luigi Pugnetti and Pietro Cecconi and Giuseppe Baselli and Mario Clerici and Raffaello Nemni and Francesca Baglio",
note = "Copyright{\circledC} Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.",
year = "2018",
month = "11",
day = "23",
doi = "10.2174/1567202616666181123164235",
language = "English",
journal = "Current Neurovascular Research",
issn = "1567-2026",
publisher = "Bentham Science Publishers B.V.",

}

TY - JOUR

T1 - Are cerebral perfusion and atrophy linked in multiple sclerosis?

T2 - Evidence for a multifactorial approach to assess neurodegeneration

AU - Laganà, Maria Marcella

AU - Mendozzi, Laura

AU - Pelizzari, Laura

AU - Bergsland, Niels Peter

AU - Pugnetti, Luigi

AU - Cecconi, Pietro

AU - Baselli, Giuseppe

AU - Clerici, Mario

AU - Nemni, Raffaello

AU - Baglio, Francesca

N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

PY - 2018/11/23

Y1 - 2018/11/23

N2 - Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC). GM volume and cerebral blood flow (CBF) differences and their correlation were tested with a voxel-wise approach. Results MS patients (41.4±12.5 years; 14 females) had a median [25th-75th percentile range] Expanded Disability Status Scale of 1.0[1.0-2.4] and a median [25th - 75th percentile range] disease duration of 8.0 [4.0 - 16.5] years. HC were age- and sex-matched (43.9±17.4 years; 11 females). GM atrophy was detected for MS group in the right parahippocampal gyrus, thalami and left caudate (pFWE≤0.05). Areas of significant (after family wise error -FWE- correction for multiple comparisons) (pFWE≤0.05) hypoperfusion were found for MS in the anterior cingulate and paracingulate gyri, supplementary motor cortex, precentral and superior frontal gyrus. GM volume and CBF showed a significant correlation (pFWE≤0.05) in the right lateral occipital cortex and precuneus in the MS group. Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume.

AB - Background Grey matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consistently reported. Since hypoperfusion might be related to atrophy, we evaluated the presence of both damages. Objective We aimed to assess if the regions of altered perfusion and atrophy overlapped with one another and if the two parameters were locally related. Method 3D-T1 weighted and arterial spin labelling sequences were acquired using a 1.5T Magnetic Resonance Imaging scanner from 26 relapsing remitting MS patients and 26 healthy controls (HC). GM volume and cerebral blood flow (CBF) differences and their correlation were tested with a voxel-wise approach. Results MS patients (41.4±12.5 years; 14 females) had a median [25th-75th percentile range] Expanded Disability Status Scale of 1.0[1.0-2.4] and a median [25th - 75th percentile range] disease duration of 8.0 [4.0 - 16.5] years. HC were age- and sex-matched (43.9±17.4 years; 11 females). GM atrophy was detected for MS group in the right parahippocampal gyrus, thalami and left caudate (pFWE≤0.05). Areas of significant (after family wise error -FWE- correction for multiple comparisons) (pFWE≤0.05) hypoperfusion were found for MS in the anterior cingulate and paracingulate gyri, supplementary motor cortex, precentral and superior frontal gyrus. GM volume and CBF showed a significant correlation (pFWE≤0.05) in the right lateral occipital cortex and precuneus in the MS group. Conclusions GM atrophy and hypoperfusion in MS were located in different areas. Perfusion estimate might be used as a further marker of tissue damage, in addition to GM volume.

U2 - 10.2174/1567202616666181123164235

DO - 10.2174/1567202616666181123164235

M3 - Article

C2 - 30468125

JO - Current Neurovascular Research

JF - Current Neurovascular Research

SN - 1567-2026

ER -