Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study

Stefano Bonassi; Angelo Abbondandolo; Lamberto Camurri; Leda Dal Prá; Marcella De Ferrari; Francesca Degrassi; Alessandra Forni; Laura Lamberti; Cecilia Lando; Paola Padovani; Isabella Sbrana; Daniela Vecchio; Riccardo Puntoni

doi:10.1016/0165-4608(94)00131-T

Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study

Stefano Bonassi, Angelo Abbondandolo, Lamberto Camurri, Leda Dal Prá, Marcella De Ferrari, Francesca Degrassi, Alessandra Forni, Laura Lamberti, Cecilia Lando, Paola Padovani, Isabella Sbrana, Daniela Vecchio, Riccardo Puntoni

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the last 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.

Original language	English
Pages (from-to)	133-135
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	79
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(94)00131-T
Publication status	Published - 1995

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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Bonassi, S., Abbondandolo, A., Camurri, L., Dal Prá, L., De Ferrari, M., Degrassi, F., Forni, A., Lamberti, L., Lando, C., Padovani, P., Sbrana, I., Vecchio, D., & Puntoni, R. (1995). Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genetics and Cytogenetics, 79(2), 133-135. https://doi.org/10.1016/0165-4608(94)00131-T

Bonassi, S, Abbondandolo, A, Camurri, L, Dal Prá, L, De Ferrari, M, Degrassi, F, Forni, A, Lamberti, L, Lando, C, Padovani, P, Sbrana, I, Vecchio, D & Puntoni, R 1995, 'Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study', Cancer Genetics and Cytogenetics, vol. 79, no. 2, pp. 133-135. https://doi.org/10.1016/0165-4608(94)00131-T

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title = "Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study",

abstract = "To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the last 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.",

author = "Stefano Bonassi and Angelo Abbondandolo and Lamberto Camurri and {Dal Pr{\'a}}, Leda and {De Ferrari}, Marcella and Francesca Degrassi and Alessandra Forni and Laura Lamberti and Cecilia Lando and Paola Padovani and Isabella Sbrana and Daniela Vecchio and Riccardo Puntoni",

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doi = "10.1016/0165-4608(94)00131-T",

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T1 - Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study

AU - Bonassi, Stefano

AU - Abbondandolo, Angelo

AU - Camurri, Lamberto

AU - Dal Prá, Leda

AU - De Ferrari, Marcella

AU - Degrassi, Francesca

AU - Forni, Alessandra

AU - Lamberti, Laura

AU - Lando, Cecilia

AU - Padovani, Paola

AU - Sbrana, Isabella

AU - Vecchio, Daniela

AU - Puntoni, Riccardo

PY - 1995

Y1 - 1995

N2 - To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the last 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.

AB - To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the last 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.

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JO - Cancer Genetics and Cytogenetics

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Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study

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