TY - JOUR
T1 - Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study
AU - Bonassi, Stefano
AU - Abbondandolo, Angelo
AU - Camurri, Lamberto
AU - Dal Prá, Leda
AU - De Ferrari, Marcella
AU - Degrassi, Francesca
AU - Forni, Alessandra
AU - Lamberti, Laura
AU - Lando, Cecilia
AU - Padovani, Paola
AU - Sbrana, Isabella
AU - Vecchio, Daniela
AU - Puntoni, Riccardo
PY - 1995
Y1 - 1995
N2 - To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the last 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.
AB - To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the last 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.
UR - http://www.scopus.com/inward/record.url?scp=0028988262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028988262&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(94)00131-T
DO - 10.1016/0165-4608(94)00131-T
M3 - Article
C2 - 7889505
AN - SCOPUS:0028988262
VL - 79
SP - 133
EP - 135
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -