Genetic and environmental factors contribute to disease Multiple Sclerosis (MS) susceptibility, the most prevalent neurological pathology affecting young individuals in Western countries.We focused our attention on HSP70-2, an inducible chaperon induced under stress conditions.Genotype analysis of HSP70-2 (+. 1267 A/G) polymorphism revealed a significant association between the minor allele G and presence of MS (OR:1.31, 95% CI: 1.02-1.69, P. =. 0.039). In addition, Hsp70-2 protein content in vitro from PBMC was significantly lower in MS patients with GG genotype compared to AA genotype, indicating an implication of the G allele of HSP70-2 gene polymorphism in the development of MS.
- HSP70-2 (+1267 A/G) polymorphism
- Multiple Sclerosis
ASJC Scopus subject areas
- Clinical Neurology
- Immunology and Allergy