Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?

Chiara Boiocchi, Cecilia Osera, Maria Cristina Monti, Ottavia Eleonora Ferraro, Stefano Govoni, Mariaclara Cuccia, Cristina Montomoli, Alessia Pascale, Roberto Bergamaschi

Research output: Contribution to journalArticle

Abstract

Genetic and environmental factors contribute to disease Multiple Sclerosis (MS) susceptibility, the most prevalent neurological pathology affecting young individuals in Western countries.We focused our attention on HSP70-2, an inducible chaperon induced under stress conditions.Genotype analysis of HSP70-2 (+. 1267 A/G) polymorphism revealed a significant association between the minor allele G and presence of MS (OR:1.31, 95% CI: 1.02-1.69, P. =. 0.039). In addition, Hsp70-2 protein content in vitro from PBMC was significantly lower in MS patients with GG genotype compared to AA genotype, indicating an implication of the G allele of HSP70-2 gene polymorphism in the development of MS.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalJournal of Neuroimmunology
Volume268
Issue number1-2
DOIs
Publication statusPublished - 2014

Keywords

  • HSP70-2 (+1267 A/G) polymorphism
  • Multiple Sclerosis
  • Neuroinflammation

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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  • Cite this

    Boiocchi, C., Osera, C., Monti, M. C., Ferraro, O. E., Govoni, S., Cuccia, M., Montomoli, C., Pascale, A., & Bergamaschi, R. (2014). Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation? Journal of Neuroimmunology, 268(1-2), 84-88. https://doi.org/10.1016/j.jneuroim.2014.01.004