Are international guidelines for the prescription of adjuvant treatment for early breast cancer followed in clinical practice? Results of a population-based study on 1547 patients

Mauro Palazzi, Dolores De Tomasi, Caterina D'Affronto, Antonella Richetti, Maria Carla Valli, Sofia Meregalli, Diego Asnaghi, Virginia Arienti, Dario Cavallini, Renato Pradella, Ines Cafaro, Gianni Baroncelli, Innocenzo Di Lorenzo, Antonio De Agostini, Giovanni Parrinello, Filippo Bertoni

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Abstract

Aims and background: The results of several randomized trials and meta-analyses have been reported on adjuvant treatment for early breast cancer and treatment guidelines have been defined accordingly, but detailed data are lacking on the appropriateness of treatment prescription in clinical practice. Methods: We performed a prospective, observational, multicenter study to monitor the prescription, delivery and effectiveness of radiotherapy following conservative surgery for early breast cancer; 1610 patients treated with postoperative radiation to the breast in 1997 were entered by 12 centers in Lombardy, Italy. Here we report the results of a secondary analysis focused on the prescription of medical adjuvant treatment (1547 eligible patients). Results: Chemotherapy only was prescribed to 526 patients (33%), hormonal therapy only to 539 (33%), and both treatments to 85 patients (5%); 460 women (29%) received no medical adjuvant treatment. We compared the collected data with guidelines defined in 1995 by the St Gallen Consensus Conference. Undertreatment was most frequent in node-negative patients at intermediate/high risk, no treatment (instead of tamoxifen or chemotherapy) being prescribed in 21-45% of cases. Node-negative patients at low risk, on the other hand, were overtreated with tamoxifen in 31% of cases. In node-positive, premenopausal women compliance with guidelines was far better, with a 91-96% rate of chemotherapy prescription. In node-positive, postmenopausal, estrogen receptor-positive patients chemotherapy was unduly prescribed in as many as 56% of cases. Comparison of clinical practice with the next version of the guidelines (1998) showed a somewhat better compliance. Conclusions: Despite the availability of official and authoritative guidelines, adjuvant treatment prescription for early breast cancer in Lombardy in 1997 was suboptimal, especially in well-defined subgroups of patients.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalTumori
Volume88
Issue number6
Publication statusPublished - Nov 2002

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Prescriptions
Guidelines
Breast Neoplasms
Population
Drug Therapy
Therapeutics
Tamoxifen
Estrogen Receptors
Italy
Compliance
Multicenter Studies
Observational Studies
Meta-Analysis
Breast
Radiotherapy
Radiation

Keywords

  • Adjuvant treatment
  • Breast cancer
  • Population-based study
  • Treatment guidelines

ASJC Scopus subject areas

  • Cancer Research

Cite this

Palazzi, M., De Tomasi, D., D'Affronto, C., Richetti, A., Valli, M. C., Meregalli, S., ... Bertoni, F. (2002). Are international guidelines for the prescription of adjuvant treatment for early breast cancer followed in clinical practice? Results of a population-based study on 1547 patients. Tumori, 88(6), 503-506.

Are international guidelines for the prescription of adjuvant treatment for early breast cancer followed in clinical practice? Results of a population-based study on 1547 patients. / Palazzi, Mauro; De Tomasi, Dolores; D'Affronto, Caterina; Richetti, Antonella; Valli, Maria Carla; Meregalli, Sofia; Asnaghi, Diego; Arienti, Virginia; Cavallini, Dario; Pradella, Renato; Cafaro, Ines; Baroncelli, Gianni; Di Lorenzo, Innocenzo; De Agostini, Antonio; Parrinello, Giovanni; Bertoni, Filippo.

In: Tumori, Vol. 88, No. 6, 11.2002, p. 503-506.

Research output: Contribution to journalArticle

Palazzi, M, De Tomasi, D, D'Affronto, C, Richetti, A, Valli, MC, Meregalli, S, Asnaghi, D, Arienti, V, Cavallini, D, Pradella, R, Cafaro, I, Baroncelli, G, Di Lorenzo, I, De Agostini, A, Parrinello, G & Bertoni, F 2002, 'Are international guidelines for the prescription of adjuvant treatment for early breast cancer followed in clinical practice? Results of a population-based study on 1547 patients', Tumori, vol. 88, no. 6, pp. 503-506.
Palazzi, Mauro ; De Tomasi, Dolores ; D'Affronto, Caterina ; Richetti, Antonella ; Valli, Maria Carla ; Meregalli, Sofia ; Asnaghi, Diego ; Arienti, Virginia ; Cavallini, Dario ; Pradella, Renato ; Cafaro, Ines ; Baroncelli, Gianni ; Di Lorenzo, Innocenzo ; De Agostini, Antonio ; Parrinello, Giovanni ; Bertoni, Filippo. / Are international guidelines for the prescription of adjuvant treatment for early breast cancer followed in clinical practice? Results of a population-based study on 1547 patients. In: Tumori. 2002 ; Vol. 88, No. 6. pp. 503-506.
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abstract = "Aims and background: The results of several randomized trials and meta-analyses have been reported on adjuvant treatment for early breast cancer and treatment guidelines have been defined accordingly, but detailed data are lacking on the appropriateness of treatment prescription in clinical practice. Methods: We performed a prospective, observational, multicenter study to monitor the prescription, delivery and effectiveness of radiotherapy following conservative surgery for early breast cancer; 1610 patients treated with postoperative radiation to the breast in 1997 were entered by 12 centers in Lombardy, Italy. Here we report the results of a secondary analysis focused on the prescription of medical adjuvant treatment (1547 eligible patients). Results: Chemotherapy only was prescribed to 526 patients (33{\%}), hormonal therapy only to 539 (33{\%}), and both treatments to 85 patients (5{\%}); 460 women (29{\%}) received no medical adjuvant treatment. We compared the collected data with guidelines defined in 1995 by the St Gallen Consensus Conference. Undertreatment was most frequent in node-negative patients at intermediate/high risk, no treatment (instead of tamoxifen or chemotherapy) being prescribed in 21-45{\%} of cases. Node-negative patients at low risk, on the other hand, were overtreated with tamoxifen in 31{\%} of cases. In node-positive, premenopausal women compliance with guidelines was far better, with a 91-96{\%} rate of chemotherapy prescription. In node-positive, postmenopausal, estrogen receptor-positive patients chemotherapy was unduly prescribed in as many as 56{\%} of cases. Comparison of clinical practice with the next version of the guidelines (1998) showed a somewhat better compliance. Conclusions: Despite the availability of official and authoritative guidelines, adjuvant treatment prescription for early breast cancer in Lombardy in 1997 was suboptimal, especially in well-defined subgroups of patients.",
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AU - Richetti, Antonella

AU - Valli, Maria Carla

AU - Meregalli, Sofia

AU - Asnaghi, Diego

AU - Arienti, Virginia

AU - Cavallini, Dario

AU - Pradella, Renato

AU - Cafaro, Ines

AU - Baroncelli, Gianni

AU - Di Lorenzo, Innocenzo

AU - De Agostini, Antonio

AU - Parrinello, Giovanni

AU - Bertoni, Filippo

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N2 - Aims and background: The results of several randomized trials and meta-analyses have been reported on adjuvant treatment for early breast cancer and treatment guidelines have been defined accordingly, but detailed data are lacking on the appropriateness of treatment prescription in clinical practice. Methods: We performed a prospective, observational, multicenter study to monitor the prescription, delivery and effectiveness of radiotherapy following conservative surgery for early breast cancer; 1610 patients treated with postoperative radiation to the breast in 1997 were entered by 12 centers in Lombardy, Italy. Here we report the results of a secondary analysis focused on the prescription of medical adjuvant treatment (1547 eligible patients). Results: Chemotherapy only was prescribed to 526 patients (33%), hormonal therapy only to 539 (33%), and both treatments to 85 patients (5%); 460 women (29%) received no medical adjuvant treatment. We compared the collected data with guidelines defined in 1995 by the St Gallen Consensus Conference. Undertreatment was most frequent in node-negative patients at intermediate/high risk, no treatment (instead of tamoxifen or chemotherapy) being prescribed in 21-45% of cases. Node-negative patients at low risk, on the other hand, were overtreated with tamoxifen in 31% of cases. In node-positive, premenopausal women compliance with guidelines was far better, with a 91-96% rate of chemotherapy prescription. In node-positive, postmenopausal, estrogen receptor-positive patients chemotherapy was unduly prescribed in as many as 56% of cases. Comparison of clinical practice with the next version of the guidelines (1998) showed a somewhat better compliance. Conclusions: Despite the availability of official and authoritative guidelines, adjuvant treatment prescription for early breast cancer in Lombardy in 1997 was suboptimal, especially in well-defined subgroups of patients.

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