Are laboratory tests useful for monitoring the activity of lupus nephritis? A 6-year prospective study in a cohort of 228 patients with lupus nephritis

G. Moroni, A. Radice, G. Giammarresi, S. Quaglini, B. Gallelli, A. Leoni, M. L. Vecchi, P. Messa, R. A. Sinico

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To evaluate the role of immunological tests for monitoring lupus nephritis (LN) activity. Methods: C3, C4, anti-dsDNA and anti-C1q antibodies were prospectively performed over 6 years in 228 patients with LN. Results: In membranous LN only anti-C1q antibodies differentiated proteinuric flares from quiescent disease (p = 0.02). However, in this group 46% of flares occurred with a normal value of anti-CI q antibodies versus 20% in proliferative LN (p = 0.02), In patients with antipho- spholipid antibodies (APL), 33% of flares occurred with normal levels of anti-C1q antibodies versus 14.5% in patients that were APL-negative (p = 0.02). In proliferative LN, anti-CI q antibodies showed a slightly better sensitivity and specificity (80.5 and 71% respectively) than other tests for the diagnosis of renal flares. All four tests had good negative predictive value (NPV). At univariate analysis anti-C1q was the best renal flare predictor (p

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume68
Issue number2
DOIs
Publication statusPublished - Feb 2009

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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