Are MODIC Type 2 disc changes associated with low-grade infections?

A pilot study

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs.

METHODS: Sixteen patients with Modic 2 changes were compared with 23 patients without Modic signs. Pre-operative laboratory tests and intra-operative tissue cultures were performed, according to a standardized procedure.

RESULTS: While no difference was found in pre-operative laboratory tests, intra-operative cultural examination showed positive results in 6/16 (37.5%) Modic 2 patients versus 1/23 (4.3%) in patients without Modic changes (P=0.012).

CONCLUSIONS: Although performed in a limited series of patients, this study supports the hypothesis that some cases of Modic 2 changes might be associated with the presence of low virulent bacteria.

Original languageEnglish
JournalJournal of Neurosurgical Sciences
DOIs
Publication statusE-pub ahead of print - Feb 15 2017

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Infection
Low Back Pain
Bacteria

Keywords

  • Journal Article

Cite this

@article{750a0b2c7c1f4d7c92412d1c5eca25dc,
title = "Are MODIC Type 2 disc changes associated with low-grade infections?: A pilot study",
abstract = "BACKGROUND: The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs.METHODS: Sixteen patients with Modic 2 changes were compared with 23 patients without Modic signs. Pre-operative laboratory tests and intra-operative tissue cultures were performed, according to a standardized procedure.RESULTS: While no difference was found in pre-operative laboratory tests, intra-operative cultural examination showed positive results in 6/16 (37.5{\%}) Modic 2 patients versus 1/23 (4.3{\%}) in patients without Modic changes (P=0.012).CONCLUSIONS: Although performed in a limited series of patients, this study supports the hypothesis that some cases of Modic 2 changes might be associated with the presence of low virulent bacteria.",
keywords = "Journal Article",
author = "Lorenzo Drago and Roman{\`o}, {Carlo L} and Riccardo Cecchinato and Villafa{\~n}e, {Jorge H} and {De Vecchi}, Elena and Claudio Lamartina and Pedro Berjano",
year = "2017",
month = "2",
day = "15",
doi = "10.23736/S0390-5616.17.03997-2",
language = "English",
journal = "Journal of Neurosurgical Sciences",
issn = "0026-4881",
publisher = "Edizioni Minerva Medica S.p.A.",

}

TY - JOUR

T1 - Are MODIC Type 2 disc changes associated with low-grade infections?

T2 - A pilot study

AU - Drago, Lorenzo

AU - Romanò, Carlo L

AU - Cecchinato, Riccardo

AU - Villafañe, Jorge H

AU - De Vecchi, Elena

AU - Lamartina, Claudio

AU - Berjano, Pedro

PY - 2017/2/15

Y1 - 2017/2/15

N2 - BACKGROUND: The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs.METHODS: Sixteen patients with Modic 2 changes were compared with 23 patients without Modic signs. Pre-operative laboratory tests and intra-operative tissue cultures were performed, according to a standardized procedure.RESULTS: While no difference was found in pre-operative laboratory tests, intra-operative cultural examination showed positive results in 6/16 (37.5%) Modic 2 patients versus 1/23 (4.3%) in patients without Modic changes (P=0.012).CONCLUSIONS: Although performed in a limited series of patients, this study supports the hypothesis that some cases of Modic 2 changes might be associated with the presence of low virulent bacteria.

AB - BACKGROUND: The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs.METHODS: Sixteen patients with Modic 2 changes were compared with 23 patients without Modic signs. Pre-operative laboratory tests and intra-operative tissue cultures were performed, according to a standardized procedure.RESULTS: While no difference was found in pre-operative laboratory tests, intra-operative cultural examination showed positive results in 6/16 (37.5%) Modic 2 patients versus 1/23 (4.3%) in patients without Modic changes (P=0.012).CONCLUSIONS: Although performed in a limited series of patients, this study supports the hypothesis that some cases of Modic 2 changes might be associated with the presence of low virulent bacteria.

KW - Journal Article

U2 - 10.23736/S0390-5616.17.03997-2

DO - 10.23736/S0390-5616.17.03997-2

M3 - Article

JO - Journal of Neurosurgical Sciences

JF - Journal of Neurosurgical Sciences

SN - 0026-4881

ER -