Are morphology and composition of gallstones related? An x-ray diffraction study

N. Bassi, G. Del Favero, T. Meggiato, P. Scalon, S. Ghiro, M. Molin, A. Pilotto, S. Vigneri, V. Savarino, G. S. Mela, F. Di Mario

Research output: Contribution to journalArticle

Abstract

An x-ray diffractometric technique was used to study the crystalline composition of gallstones removed during surgery from 106 patients. Monohydrate cholesterol was found in the stones of 70 (66%) patients, either alone (33%) or in association with calcium salts (33%). The anhydrous form of cholesterol was found in the stones of 28 (26%) patients, either alone (10%) or in association with calcium salts (16%). These salts (vaterite, aragonite, and calcite) were found in 50% of cases in varying amounts (from 12% to 15% of the stone weight). Eight stones contained no cholesterol: 4 showed an amorphous pattern and 4 were composed of calcium carbonate salts. In 7 of 8 patients with bile duct stones concomitant with gallbladder stones, results of the diffractograms of the stones from the two different sites were comparable, even in 4 cases in which the stones were macroscopically different. Neither the macroscopic appearance nor the chemical structure of the stones appeared to be influenced by the patient's sex.

Original languageEnglish
Pages (from-to)1169-1175
Number of pages7
JournalCurrent Therapeutic Research
Volume55
Issue number10
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine(all)

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    Bassi, N., Del Favero, G., Meggiato, T., Scalon, P., Ghiro, S., Molin, M., Pilotto, A., Vigneri, S., Savarino, V., Mela, G. S., & Di Mario, F. (1994). Are morphology and composition of gallstones related? An x-ray diffraction study. Current Therapeutic Research, 55(10), 1169-1175. https://doi.org/10.1016/S0011-393X(05)80257-7