Are nanotechnological approaches the future of treating inflammatory diseases?

Maria Antonietta Rizzuto, Lucia Salvioni, Rany Rotem, Miriam Colombo, Ivan Zanoni, Francesca Granucci, Davide Prosperi

Research output: Contribution to journalArticle

Abstract

The current treatments for chronic inflammatory diseases cause severe side effects due to nonspecific drug accumulation. Nanotechnology opens the way to new therapeutic strategies that exploit the ability of immune cells, and especially of phagocytes, to internalize nanoparticles. The cellular uptake of nanoparticles requires specific interactions and is affected by the chemical and physical properties of the carriers. Therefore, optimizing these properties is crucial for designing nanodrugs for immunotherapy. In perspective, we discuss the nanoparticle-based approaches that have been proposed to induce tolerance in autoimmune disorders and lessen the symptoms of inflammatory diseases.

Original languageEnglish
Pages (from-to)2379-2390
Number of pages12
JournalNanomedicine
Volume14
Issue number17
DOIs
Publication statusPublished - Sep 2019

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Rizzuto, M. A., Salvioni, L., Rotem, R., Colombo, M., Zanoni, I., Granucci, F., & Prosperi, D. (2019). Are nanotechnological approaches the future of treating inflammatory diseases? Nanomedicine, 14(17), 2379-2390. https://doi.org/10.2217/nnm-2019-0159