Are referral centers for non-muscle-invasive bladder cancer compliant to EAU guidelines? A report from the vesical antiblastic therapy Italian study

Paolo Gontero, Marco Oderda, Vincenzo Altieri, Riccardo Bartoletti, Tommaso Cai, Renzo Colombo, Antonio Curotto, Savino Di Stasi, Massimo Maffezzini, Stefania Tamagno, Vincenzo Serretta, Filippo Sogni, Carlo Terrone, Alessandro Tizzani, Giuseppe Morgia, Vincenzo Mirone, Giorgio Carmignani

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Adherence to international guidelines is viewed as a prerequisite for optimal medical care delivery. Previously reported surveys for non-muscle-invasive bladder cancer (NMIBC) employed mailed questionnaires to urologists or patients resulting in conflicting degrees of agreement with existing guidelines. In the current study, contemporary information on the management of NMIBC was generated from a sample of Italian centers. Patients and Methods: Eight Italian referral centers for the treatment of NMIBC were asked to collect information relative to all consecutive patients with a histology-proven NMIBC undergoing a transurethral resection from January 1 to March 31, 2009. The primary study objective was to verify the level of adherence of disease management with European guidelines. Results: 344 patients resulted in being evaluable. 49.2% of high-risk patients underwent a repeat transurethral resection. Bacillus Calmette-Guérin was employed in 35% of cases, while chemotherapy was in 22%. An early single regimen was adopted in 136 patients and only in 1 out of 3 low-risk patients. High-risk NMIBC received bacillus Calmette-Guérin and chemotherapy as first-line therapy in 66 and 12.5% respectively. After 3 months, cystoscopy had been reported for 82.5% of patients with a recurrence rate of 13%. Conclusion: Adherence of Italian Institutions to EAU guidelines was optimal when reporting baseline variables. Significant degrees of discrepancy emerged in treatment choices.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalUrologia Internationalis
Volume86
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Bladder cancer
  • EAU guidelines
  • Intravesical therapy
  • Non-muscle-invasive bladder cancer

ASJC Scopus subject areas

  • Urology

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