Subcorneal pustular dermatosis (SPD) of Sneddon-Wilkinson is a rare, recurrent condition characterized by annular, circinate, pustular lesions localized on neck and flexures. Histologically, the presence of a subcorneal pustule filled with neutrophils is typical but not distinctive. The relationship between SPD and pustular psoriasis has long been debated, since on clinical grounds SPD is distinguishable from pustular psoriasis, but histopathologically its findings are virtually indistinguishable from those of psoriasis and in particular pustular psoriasis. We have observed a 63-year old female patient with typical SPD. She responded well to photochemotherapy and systemic retinoids. After a relapse, the patient inadequately used a topical steroid cream for about 6 months. When she was seen again, she presented typical nummular psoriatic plaques on the buttocks, elbows, knees, associated with the pre-existing features of diffuse SPD on the trunk, abdomen and neck. The evolution in this case from a typical SPD into psoriasis and disseminated pustular eruption, highlights both the possibility of a common pathogenesis between SPD and psoriasis, and the role of a topical steroid as a possible drug induced triggering factor in the appearance of psoriasis in a patient affected by SPD.
|Translated title of the contribution||Are Sneddon-Wilkinson disease and psoriasis part of the same spectrum? Case report|
|Number of pages||4|
|Journal||Annali Italiani di Dermatologia Clinica e Sperimentale|
|Publication status||Published - 1995|
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