Are Some People Protected Against HIV Infection?

Mario Clerici, Mara Biasin, Gene M. Shearer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter briefly describes host genetics, genesis of the field, and many other concepts. Host genetic factors play an important role in resistance to human immunodeficiency virus (HIV) infection shaping different steps in the viral cycle as well as in immune responses to HIV antigens. The most significant genetic correlates of protection belong to two families: chemokine receptors/ligands and human leukocyte antigens (HLAs). In addition, immune responses to viral antigens are strictly dependent on host immune response genes. HLA genes are the most prominent of such genes, because of their role in binding and presenting antigenic epitopes to T lymphocytes. Several publications describe associations of particular HLA alleles with different outcomes of human immunodeficiency virus 1 (HIV-1) infection.

Original languageEnglish
Title of host publicationModels of Protection Against HIV/SIV
PublisherElsevier Inc.
Pages135-143
Number of pages9
ISBN (Print)9780123877154
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Clerici, M., Biasin, M., & Shearer, G. M. (2012). Are Some People Protected Against HIV Infection? In Models of Protection Against HIV/SIV (pp. 135-143). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-387715-4.00004-6