Are the metabolic syndrome, blood pressure pattern, and their interaction responsible for the right ventricular remodeling?

Marijana Tadic, Branislava Ivanovic, Vera Celic, Cesare Cuspidi

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The aim of our study was to define the relationship between the metabolic syndrome (MS), nondipping pattern, and their interaction on right ventricular (RV) structural and functional changes in untreated hypertensive patients. METHODS: This cross-sectional study included 318 recently diagnosed hypertensive patients. MS was defined by the presence of at least 3 National Cholesterol Education Program's Adult Treatment Panel III criteria. All patients underwent 24-h ambulatory blood pressure monitoring and a complete two-dimensional echocardiography examination. RESULTS: MS was found in 144 (45%) hypertensive patients and the nondipping pattern was detected in 147 (46%) patients. Hypertensive patients with MS had higher 24-h and night-time blood pressure levels in comparison with non-MS patients with the same nocturnal blood pressure pattern. RV wall thickness was significantly increased and RV diastolic function was significantly deteriorated in nondippers (with and without MS), but still more impaired in MS patients. MS, nondipping pattern, and their interaction had a huge impact on RV wall thickness, parameters of RV diastolic function (E/At, E/e′t, e′/a′t), as well as RV global function estimated by the myocardial performance index. Among the MS criteria, only fasting glucose level and abdominal obesity were associated independently with RV hypertrophy, diastolic, and global dysfunction. CONCLUSION: MS, nondipping pattern, and their interaction significantly impact RV structure, diastolic, and global function. Fasting glucose level and abdominal obesity are the most important MS criteria for RV remodeling in arterial hypertension.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalBlood Pressure Monitoring
Volume18
Issue number4
DOIs
Publication statusPublished - Aug 2013

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Ventricular Remodeling
Blood Pressure
Right Ventricular Function
Abdominal Obesity
Fasting
Right Ventricular Hypertrophy
Glucose
Ambulatory Blood Pressure Monitoring
Echocardiography
Cross-Sectional Studies
Cholesterol
Hypertension

Keywords

  • 24-h ambulatory blood pressure monitoring
  • metabolic syndrome
  • nondipping
  • right ventricle

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Assessment and Diagnosis
  • Advanced and Specialised Nursing

Cite this

Are the metabolic syndrome, blood pressure pattern, and their interaction responsible for the right ventricular remodeling? / Tadic, Marijana; Ivanovic, Branislava; Celic, Vera; Cuspidi, Cesare.

In: Blood Pressure Monitoring, Vol. 18, No. 4, 08.2013, p. 195-202.

Research output: Contribution to journalArticle

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