Are the neurophysiological techniques useful for the diagnosis of diaphragmatic impairment in multiple sclerosis (MS)?

G. Miscio, G. Guastamacchia, L. Priano, S. Baudo, A. Mauro

Research output: Contribution to journalArticle


Objective: To characterize cortico-diaphragmatic pathway involvement in multiple sclerosis (MS) by means of transcranial magnetic stimulation (TMS), and verify its clinical impact. Methods: TMS from diaphragm (Dia), and abductor digiti minimi (AbdV°) was performed in 26 MS patients. Phrenic nerve (PN) conduction study was also performed. Expanded disability status scale (EDSS) and fatigue descriptive scale (FDS) were measured. Forced vital capacity (FVC), forced expiratory volume at the first second (FEV1), peak expiratory flow (PEF) were tested: the predicted percentage value (% pred) was considered. Results: Cortical motor evoked potential (Cx-MEP) latency and central motor conduction time (CMCT) were prolonged, respectively, in 31 and 23% of patients from Dia, in 76 and 79% from AbdV°. PN-compound motor action potential (CMAP) was normal. EDSS correlated to Cx-MEP from AbdV° (P

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalClinical Neurophysiology
Issue number1
Publication statusPublished - Jan 1 2003



  • Diaphragm
  • Multiple sclerosis
  • Phrenic nerve
  • Respiratory function
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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