Are the pure in situ breast ductal carcinomas and those associated with invasive carcinoma the same?

Mario Casales Schorr, José Luiz Pedrini, Ricardo Francalacci Savaris, Cláudio Galleano Zettler

Research output: Contribution to journalArticle

Abstract

It has been reported that pure ductal carcinoma in situ of the breast has morphologic differences from the in situ component of the invasive ductal carcinoma, as well estrogen and progesterone receptors expression according to their cytokeratin expression. However, there is no data comparing other tumor markers without using the cytokeratin expression. The objective of this study is to compare the expression of estrogen receptor (ER) and progesterone receptor (PR), HER-2/neu, p53, and Ki67 between pure ductal in situ carcinoma (pDCIS) and the in situ component of the invasive ductal carcinoma (DCIS+IDC) of the breast, and the in situ component to the invasive component of the same tumor (DCIS+IDC). The immunohistochemistry expression of the tumor markers was performed in 45 cases of pDCIS and DCIS+IDC, yielding a total of 90 cases. Statistical analysis was carried out using Fisher exact test, having a P

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalApplied Immunohistochemistry and Molecular Morphology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Breast cancer
  • Estrogen receptor
  • HER-2/neu
  • P53
  • Progesterone receptor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Histology

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